中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (49): 9306-9310.doi: 10.3969/j.issn.2095-4344.2012.49.033

• 干细胞学术探讨 stem cell academic discussion • 上一篇    

细胞因子与干细胞骨软骨分化的调节

许胜贵,林建华   

  1. 福建医科大学附属第一医院骨科,福建省福州市 350005
  • 收稿日期:2012-02-01 修回日期:2012-04-03 出版日期:2012-12-02 发布日期:2012-12-02
  • 通讯作者: 林建华,主任医师,教授,博士生导师,福建医科大学附属第一医院骨科,福建省福州市 350005 jianhua0918@126.com
  • 作者简介:许胜贵★,男,1984年生,福建省周宁县人,汉族,2012年福建医科大学毕业,硕士,主要从事骨软骨组织工程的研究。 xshgui@yahoo.com.cn

Cytokines regulate osteochondral differentiation of stem cells

Xu Sheng-gui, Lin Jian-hua   

  1. Department of Orthopedics, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China
  • Received:2012-02-01 Revised:2012-04-03 Online:2012-12-02 Published:2012-12-02
  • Contact: Lin Jian-hua, Chief physician, Professor, Doctoral supervisor, Department of Orthopedics, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China jianhua0918@ 126.com
  • About author:Xu Sheng-gui★, Master, Department of Orthopedics, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China xshgui@yahoo.com.cn

摘要:

背景:软骨修复尤其是伴软骨下骨的修复是骨关节组织工程修复的研究重点。近些年,随着人们对细胞因子研究的不断深入,寻找一种合适的细胞因子,诱导细胞骨软骨分化备受关注。
目的:综述细胞因子对干细胞骨软骨分化调节的影响。
方法:应用计算机检索2000年1月至2011年12月PubMed数据库相关文章,检索词为“chondrification,cytokine,stem cells,tissue engineering”,并限定文章语言种类为English。同时计算机检索2000年1月至2011年12月万方医学数据库相关文章,检索词为“软骨形成,细胞因子,干细胞,组织工程”,并限定文章语言种类为中文。最终纳入符合标准的文献32篇。
结果与结论:诱导干细胞成骨、成软骨分化的成功与否与诱导因子息息相关,尤其是Wnt信号通路、转化生长因子β超家族途径在干细胞成骨、成软骨分化调节过程发挥重要作用。随着对干细胞分化过程中各种调控因素的深入研究,将为体外培养和诱导干细胞的定向分化发育创造更好的条件。

关键词: 间充质干细胞, 细胞因子, 成骨分化, 成软骨分化, 综述文献

Abstract:

BACKGROUND: Cartilage repair, especially with the subchondral bone damage, has been a hot research. In recent years, with the further research of cytokines, increasing attention has been paid to find a proper cytokine and induce osteochondral differentiation of stem cells. 
OBJECTIVE: To review the regulatory effects of cytokines on osteochondral differentiation of stem cells.
METHODS: A computer-based online search of Pubmed database (http://www.Ncbi.nlm.nih.gov/PubMed) and Wanfang database (http://ww.wanfangdata.com.cn/) was performed for related articles published from January 2000 to December 2011 using the key words “chondrification, cytokine, stem cells, tissue engineering” in English and Chinese. Totally 32 papers were included in the final analysis.
RESULTS AND CONCLUSION: Cytokines, in particular, Wnt and transforming growth factor β/bone morphogenetic protein signaling pathways, play an important role in the osteochondral differentiation of stem cells. An in-depth study of various regulatory factors during the differentiation of stem cells would provide better conditions for in vitro culture and directed differentiation of stem cells in vitro.

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