中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (30): 5581-5585.doi: 10.3969/j.issn.2095-4344.2012.30.015

• 骨与关节临床实践 clinical practice of the bone and joint • 上一篇    下一篇

低功率激光对Beagle犬胫骨种植体周骨愈合的影响

范 芹1，徐世同2，刘建国1，吕 聪3   

  1. 1遵义医学院附属口腔医院口腔种植科，贵州省遵义市 563000；
    2南方医科大学附属口腔医院•广东省口腔医院种植中心，广东省广州市 510280；
    3烟台市口腔医院，山东省烟台市 264001
  • 收稿日期:2011-12-09 修回日期:2012-04-25 出版日期:2012-07-22 发布日期:2012-07-22
  • 通讯作者: 徐世同，硕士，主任医师，南方医科大学附属口腔医院?广东省口腔医院种植中心，广东省广州市 510280 xushitong621016@126.com
  • 作者简介:范芹★，女，1976年生，贵州省湄潭县人，土家族，2002年遵义医学院毕业，硕士，讲师，主要从事口腔种植骨缺损修复的研究。 fanqin.12345@163.com

Effect of low-level laser on the healing of bone tissues around the implant in tibia of Beagle dogs

Fan Qin1, Xu Shi-tong2, Liu Jian-guo1, Lü Cong3   

  1. 1Department of Oral Implantology, Stomatological Hospital Affiliated to Zunyi Medical College, Zunyi 563003, Guizhou Province, China;
    2Affiliated Stomatological Hospital of Southern Medical University, Implant Center of Guangdong Provincial Stomatological Hospital, Guangzhou 510280, Guangdong Province, China; 3Yantai Stomatological Hospital, Yantai 264001, Shandong Province, China
  • Received:2011-12-09 Revised:2012-04-25 Online:2012-07-22 Published:2012-07-22
  • Contact: Xu Shi-tong, Master, Chief physician, Affiliated Stomatological Hospital of Southern Medical University, Implant Center of Guangdong Provincial Stomatological Hospital, Guangzhou 510280, Guangdong Province, China xushitong621016@126.com
  • About author:Fan Qin★, Master, Lecturer, Department of Oral Implantology, Stomatological Hospital Affiliated to Zunyi Medical College, Zunyi 563003, Guizhou Province, China fanqin.12345@163.com

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摘要：

背景：低功率激光照射对种植体周骨愈合及骨结合的影响尚无确切的结论。
目的：探讨低功率氦氖激光局部照射对骨内种植体周骨愈合的影响。
方法：取6只Beagle犬，每只犬两侧胫骨分别植入3枚种植体，植入后分别采用低功率氦氖激光局部照射1周，2周或不照射。分别于第4，8，12周随机处死2只Beagle犬取材。
结果与结论：亚甲基蓝-酸性品红染色显示，给予低功率氦氖激光局部照射的种植体周骨组织愈合优于未照射者。骨形态计量学分析结果显示，随着种植体植入时间的延长，种植体-骨结合率逐渐增高；在相同时间点，种植体-骨结合率以照射2周组最高，照射1周组次之。提示低功率氦氖激光局部照射能显著促进种植体周骨组织愈合及其改建成熟，同时增加种植体骨结合面积。

关键词: 低功率激光, 种植体, 骨形态计量学, 骨愈合, 骨结合

Abstract:

BACKGROUND: There is no definitive conclusion for the effect of low-level laser irradiation on the healing and osseointegration of bone tissues around the implant.
OBJECTIVE: To investigate the effect of low-level He-Ne laser irradiation on the healing of bone tissues around the implant.
METHODS: Thirty-six implants were randomly divided into three groups and planted into both sides of tibia of six Beagle dogs. The dogs were received low-level He-Ne laser irradiation for 1 and 2 weeks, but the dogs in the control group did not receive laser irradiation. Two dogs were randomly euthanized at 4, 8 and 12 weeks respectively.
RESULTS AND CONCLUSION: Methylene blue-acid fuchsin staining showed that the healing degrees of the bone tissue around the implant were higher by laser irradiation. Bone histomorphome showed that the bone-implant contact ratio was gradually increased in a time-depend manner; at the same time points, the bone-implant contact ratio was highest in the 2-week irradiation group, and followed by 1-week irradiation group. The results revealed that the locally low-level He-Ne laser irradiation could promote the healing of bone tissue around the implant and increase the degree of osseointegration.

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