中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (28): 5281-5286.doi: 10.3969/j.issn.2095-4344.2012.28.031

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

抗阻运动对骨骼肌肥厚的影响

文 安1, 2，史清钊3，赵 楠4   

  1. 1上海体育学院研究生部，上海市 200438；
    2西安工业大学体育学院，陕西省西安市 710032；首都体育学院，
    3保健康复教研室，
    4竞技体校，北京市100191
  • 收稿日期:2012-04-09 修回日期:2012-04-23 出版日期:2012-07-08 发布日期:2012-07-08
  • 作者简介:文安☆，男，1972年，陕西省西安市人，汉族，上海体育学院在读博士，副教授，主要从事运动人体科学方面的研究。 awen0015@yahoo.com.cn

Resistance exercise effects on skeletal muscle hypertrophy

Wen An1, 2, Shi Qing-zhao3, Zhao Nan4   

  1. 1School of Graduate, Shanghai University of Sport, Shanghai 200438, China;
    2School of Physical Education, Xi’an University of Technology, Xi’an 710032, Shaanxi Province, China;
    3Health Care and Rehabilitation Department,
    4Sports School, Capital Institute of Physical Education, Beijing 100191, China
  • Received:2012-04-09 Revised:2012-04-23 Online:2012-07-08 Published:2012-07-08
  • About author:Wen An☆, Studying for doctorate, Associate professor, School of Graduate, Shanghai University of Sport, Shanghai 200438, China; School of Physical Education, Xi’an University of Technology, Xi’an 710032, Shaanxi Province, China awen0015@yahoo.com.cn

PDF

870

被引次数

15

摘要：

背景：抗阻运动能促进骨骼肌生长，导致骨骼肌肥厚。
目的：对目前采用细胞生物学及分子生物学方法观察抗阻运动对骨骼肌影响的文献进行综述。
方法：检索PubMed数据库中1999/2011-05收录的与抗阻运动后骨骼肌肥厚相关的文章，经筛选共纳入45篇文献，通过PubMed获得文献摘要及部分文献原文，如果没有全文通过Springer或Sciencedirect数据库或其他原文传递方式获得全文，分析抗阻运动对骨骼肌肥厚的研究进展。
结果与结论：抗阻运动后循环同化激素包括生长激素、胰岛素样生长因子1和睾酮发生应答性变化，对骨骼肌肥厚产生影响。抗阻运动对骨骼肌细胞生物学影响的研究主要集中在雷帕霉素靶蛋白介导骨骼肌蛋白合成途径，前列腺素、肿瘤坏死因子α介导的炎性机制与增肌关系和张力感受器在信号改变后对增肌的影响3个方面。

关键词: 抗阻运动, 激素应答, 雷帕霉素, 张力感受器, 骨骼肌肥厚, 细胞因子

Abstract:

BACKGROUND: Resistance exercise can promote muscle growth, resulting in skeletal muscle hypertrophy.
OBJECTIVE: To review the literature addressing the influence of resistance exercise on skeletal muscle by using cell biology and molecular biology method.
METHODS: PubMed (1999/2011-05) was electronically retrieved for articles related to resistance exercise effects on skeletal muscle hypertrophy, and then 45 articles were adopted by explicating inclusion and exclusion. The abstracts and the part of texts were obtained through the PubMed, and Springer or Sciencedirect was searched to get full texts so as to analyze the research progress of resistance exercise effects on skeletal muscle hypertrophy.
RESULTS AND CONCLUSION: The response of circulation assimilation hormones including growth hormone, insulin-like growth factor-1 and testosterone level change to resistance exercise and the internal environment factors have the significant effects on skeletal muscle hypertrophy. The cellular biological effects of resistance exercise on skeletal muscle are also further discussed. This field is focused on the methods of mammalian target of rapamycin mediating skeletal muscle protein synthesis, inflammation mechanism of prostaglandins and tumor necrosis factor α, and influence of tension-sensor to adding muscles after signal changing.

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