中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (17): 2746-2752.doi: 10.3969/j.issn.2095-4344.1714

• 干细胞综述 stem cell review • 上一篇    下一篇

衰老与肺纤维化和慢性阻塞性肺疾病以及间充质干细胞的治疗作用

杨育坤,朱向情,阮光萍,王严影,阚晓丽,张学娟,于倩倩,王 茂,何环宇,潘兴华   

  1. 中国人民解放军联勤保障部队第920医院,干细胞与免疫细胞生物医药技术国家地方联合工程实验室,云南省细胞治疗技术转化医学重点实验室,云南省干细胞工程实验室,云南省昆明市 652230
  • 修回日期:2019-01-23 出版日期:2019-06-18 发布日期:2019-06-18
  • 通讯作者: 潘兴华,博士,博士后,主任医师,教授,博士生导师,中国人民解放军联勤保障部队第920医院,干细胞与免疫细胞生物医药技术国家地方联合工程实验室,云南省细胞治疗技术转化医学重点实验室,云南省干细胞工程实验室,云南省昆明市 652230
  • 作者简介:杨育坤,男,1993年生,四川省江油市人,汉族,昆明医科大学在读硕士,主要从事间充质干细胞研究。
  • 基金资助:

    云南省重大科技专项计划:干细胞技术及临床转化研究(2018ZF007),项目负责人:潘兴华;云南省科技计划面上项目:成体细胞重编程基因表达信号动态变化及分子互作网络(2017FB042),项目负责人:朱向情

Association of aging with pulmonary fibrosis and chronic obstructive pulmonary disease and treatment with mesenchymal stem cells

Yang Yukun, Zhu Xiangqing, Ruan Guangping, Wang Yanying, Kan Xiaoli, Zhang Xuejuan, Yu Qianqian, Wang Mao, He Huanyu, Pan Xinghua   

  1. Yunnan Stem Cell Engineering Laboratory, Yunnan Provincial Key Laboratory of Cell Therapy and Translational Medicine, National and Local Joint Engineering Laboratory of Stem Cell and Immune Cell Biomedical Technology, 920th Hospital of Joint Logistics Support Force of PLA, Kunming 652230, Yunnan Province, China
  • Revised:2019-01-23 Online:2019-06-18 Published:2019-06-18
  • Contact: Pan Xing-hua, MD, Chief physician, Professor, Doctoral supervisor, Yunnan Stem Cell Engineering Laboratory, Yunnan Provincial Key Laboratory of Cell Therapy and Translational Medicine, National and Local Joint Engineering Laboratory of Stem Cell and Immune Cell Biomedical Technology, 920th Hospital of Joint Logistics Support Force of PLA, Kunming 652230, Yunnan Province, China
  • About author:Yang Yukun, Master candidate, Yunnan Stem Cell Engineering Laboratory, Yunnan Provincial Key Laboratory of Cell Therapy and Translational Medicine, National and Local Joint Engineering Laboratory of Stem Cell and Immune Cell Biomedical Technology, 920th Hospital of Joint Logistics Support Force of PLA, Kunming 652230, Yunnan Province, China
  • Supported by:

    the Major Science and Technology Special Plan of Yunnan Province, No. 2018ZF007 (to PXH); the Science and Technology Plan Project of Yunnan Province, No. 2017FB042 (to ZXQ)

摘要:

文章快速阅读:

文题释义:
特发性肺纤维化:
是一种慢性、进行性、病因不清的纤维化性间质性肺疾病,其病变局限在肺脏,好发于中老年人群。临床上,它的特点是起病隐匿的呼吸困难和用力、干性咳嗽,进而发生进行性的呼吸困难。肺组织学和/或胸部高分辨率CT特征性表现为普通型间质性肺炎,病理表现为间质炎症少、胶原斑片状纤维化、成纤维细胞增生灶明显,显微镜可见蜂窝状改变。
丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK):是能被细胞因子、神经递质、激素、细胞应激及细胞黏附等激活的丝氨酸-苏氨酸蛋白激酶。由于丝裂原活化蛋白激酶是培养细胞在受到生长因子等丝裂原刺激时激活而被鉴定的,因而得名。所有的真核细胞都能表达丝裂原活化蛋白激酶。丝裂原活化蛋白激酶通路包括三级激酶模式,共同调节细胞的生长分化、对环境的应激适应、炎症反应等多种重要的细胞生理/病理过程。

 

摘要
背景:
衰老与肺纤维化、慢性阻塞性肺疾病的发生发展密切相关,间充质干细胞可能对衰老相关的肺纤维化和慢性阻塞性肺疾病有治疗作用。
目的:综述衰老与肺纤维化和慢性阻塞性肺疾病的关系以及间充质干细胞对其治疗的效果和机制。
方法:检索PubMed数据库、CNKI数据库中2005年6月至2018年10月关于肺纤维化、慢性阻塞性肺疾病与衰老的关系以及间充质干细胞治疗慢性阻塞性肺疾病和肺纤维化的文章,中文检索词为“肺纤维化,慢性阻塞性肺疾病,衰老,间充质干细胞”,英文检索词为“pulmonary fibrosis,COPD,aging,MSCs”,排除陈旧性和无关研究,最后选择64篇文献进行综述。
结果与结论:端粒长度调节、细胞和免疫衰老、氧化应激以及许多抗衰老分子和细胞外基质的变化等与肺纤维化、慢性阻塞性肺疾病密切相关。间充质干细胞作为一种具有自我更新、多向分化和分泌活性的多功能细胞,能从抗氧化应激、调节衰老分子、减少细胞衰老与凋亡等多个衰老关键表型的角度出发,治疗与衰老有关的肺纤维化和慢性阻塞性肺疾病。


中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
ORCID: 0000-0002-9492-177X(杨育坤)

关键词: 间充质干细胞, 慢性阻塞性肺疾病, 肺纤维化, 细胞衰老, 细胞凋亡, 抗氧化应激, 端粒长度, 细胞外基质

Abstract:

BACKGROUND: Aging is closely related to the occurrence and development of pulmonary fibrosis and chronic obstructive pulmonary disease, and mesenchymal stem cells may have therapeutic effects on senile pulmonary fibrosis and chronic obstructive pulmonary disease due to their characteristics.
OBJECTIVE: To review the relationship between aging and pulmonary fibrosis and chronic obstructive pulmonary disease, as well as the therapeutic effect and mechanism of mesenchymal stem cells.
METHODS: PubMed and CNKI database were searched for articles published from June 2005 to October 2018 on pulmonary fibrosis, the relationship between chronic obstructive pulmonary disease and aging, as well as the relationship between mesenchymal stem cells for the treatment of chronic obstructive pulmonary disease and pulmonary fibrosis. The key words in Chinese were “pulmonary fibrosis, chronic obstructive pulmonary disease, aging, mesenchymal stem cells”, and the English terms were “pulmonary fibrosis, COPD, aging, MSCs.” Obsolete and unrelated studies were excluded, and finally 64 articles were reviewed.
RESULTS AND CONCLUSION: Length of the telomere, cell and immunosenescence, oxidative stress and many anti-aging molecules and changes in the extracellular matrix are closely related to pulmonary fibrosis and chronic obstructive pulmonary disease. Mesenchymal stem cells are pluripotent cells that have self-renewal, multilineage differentiation and secretion activity, adjust the aging molecules from oxidation stress, and reduce cell senescence and apoptosis, to treat pulmonary fibrosis associated with aging and chronic obstructive pulmonary disease.

Key words: mesenchymal stem cells, chronic obstructive pulmonary disease, pulmonary fibrosis, cell senescence, cell apoptosis, anti-oxidative stress, telomere length, extracellular matrix

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