中国组织工程研究

中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (5): 801-806.doi: 10.3969/j.issn.2095-4344.0454

• 干细胞综述 stem cell review • 上一篇    下一篇

干细胞源外泌体应用于再生医学的研究进展

张恩国1，2，陈尚雅2，3，杨 叶1，2，杜忠君2，邵 华2   

  1. 1济南大学 山东省医学科学院医学与生命科学学院，山东省济南市 250062；2山东省医学科学院 山东省职业卫生与职业病防治研究院，山东省济南市 250062；3山东中医药大学，山东省济南市 250355
  • 修回日期:2017-09-21 出版日期:2018-02-18 发布日期:2018-02-18
  • 通讯作者: 邵华，研究员，博士生导师，山东省医学科学院山东省职业卫生与职业病防治研究院，山东省济南市 250062； 并列通讯作者：杜忠君，硕士生导师，山东省医学科学院山东省职业卫生与职业病防治研究院，山东省济南市 250062
  • 作者简介:张恩国，男，1993年生，山东省济南市人，汉族，山东省职业卫生与职业病防治研究院在读硕士研究生，主要从事职业性肺部疾病的防治研究。
  • 基金资助:

    国家自然科学基金(81470145，81602893)；山东省自然科学基金(ZR2015YL049)；山东省医药卫生科技发展计划(2016WS0540)；山东省医学科学院创新工程

Stem cell-derived exosomes in regenerative medicine: research progress and applications

Zhang En-guo1, 2, Chen Shang-ya2, 3, Yang Ye1, 2, Du Zhong-jun2, Shao Hua2   

  1. 1School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250062, Shandong Province, China; 2Shandong Academy of Occupational Health and Occupational Medicine, Shandong Academy of Medical Sciences, Jinan 250062, Shandong Province, China; 3Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China
  • Revised:2017-09-21 Online:2018-02-18 Published:2018-02-18
  • Contact: Shao Hua, Investigator, Doctoral supervisor, Shandong Academy of Occupational Health and Occupational Medicine, Shandong Academy of Medical Sciences, Jinan 250062, Shandong Province, China; Du Zhong-jun, Master’s supervisor, Shandong Academy of Occupational Health and Occupational Medicine, Shandong Academy of Medical Sciences, Jinan 250062, Shandong Province, China
  • About author:Zhang En-guo, Master candidate, School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250062, Shandong Province, China; Shandong Academy of Occupational Health and Occupational Medicine, Shandong Academy of Medical Sciences, Jinan 250062, Shandong Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81470145, 81602893; the Natural Science Foundation of Shandong Province, No. ZR2015YL049; Shandong Provincial Medical and Health Science and Technology Development Program, No. 2016WS0540; Innovation Project of Shandong Academy of Medical Sciences

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摘要：

文章快速阅读：

文题释义：
干细胞源外泌体：干细胞通过旁分泌机制衍生的直径为30-150 nm的具有脂质双层膜的微小囊泡，可以携带和传递重要信号分子，形成一种全新的细胞间信息传递系统，参与细胞的生理状态并与多种疾病的发生与进程密切相关。
外泌体miRNA：通过循环囊泡传递信息，被认为是细胞间信号交流的第三种途径。近年来大量研究发现外泌体源性miRNA在多种疾病发生发展过程中异常表达。

 

摘要
背景：干细胞疗法作为新兴的细胞治疗手段，逐渐受到医学领域研究者的关注。干细胞治疗的机制主要包括分化和旁分泌机制。近年来，随着研究的深入，人们把视线逐渐转向了其旁分泌机制，尤其是发现干细胞衍生的外泌体在机体损伤修复保护方面的巨大潜能，可以为再生医学“无细胞”治疗提供一种强有力的修复工具。
目的：综述干细胞源外泌体对多种疾病损伤模型的修复、保护作用及其可能的生物学机制。
方法：在PubMed、CNKI和万方数据库中进行相关文献检索，关键词为“Stem cell-derived exosomes，exosome，regenerative medicine”及“外泌体，干细胞来源的外泌体，再生医学”。纳入41篇文献进行综述。
结果与结论：干细胞来源的外泌体对众多疾病都表现出强大的修复、保护能力，例如心血管系统、外伤性脑损伤、肌肉骨骼系统、肝损伤、肾损伤等。大部分研究尚未报道其详细的分子作用机制，干细胞来源的外泌体有望成为一种新兴的“无细胞”治疗方法用于机体损伤的修复及保护，打破不可逆损伤这一修复障碍，使再生成为可能。

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程
ORCID: 0000-0002-6017-9896(张恩国)

关键词: 干细胞, 外泌体, 再生医学, 组织修复, 国家自然科学基金

Abstract:

BACKGROUND: As an emerging cell therapy, stem cell therapy has gradually attracted the attention of researchers in the field of medicine. The mechanisms of stem cell therapy mainly include differentiation and paracrine mechanisms. In recent years, with the further research, people gradually put attention to paracrine mechanisms, especially after the discovery of the great protective potential of stem cell-derived exosomes which can provide a powerful repair tool for the "acellular" treatment of regenerative medicine.
OBJECTIVE: To review the repair, protection and possible biological mechanisms of stem cell-derived exosomes in various disease damage models.
METHODS: The literature search was performed in PubMed, CNKI and WanFang databases, and the keywords were “stem cell-derived exosomes, exosome, regenerative medicine” in English and Chinese, respectively. According to the inclusion and exclusion criteria, 41 articles were finally reviewed.
RESULTS AND CONCLUSION: Stem cell-derived exosomes show outstanding ability to repair and protect many diseases, such as cardiovascular system, traumatic brain injury, musculoskeletal system, liver damage, renal injury, and so on. Although most studies have yet to report their detailed molecular mechanisms of action, stem cell-derived exosomes are expected to become a new "acellular" approach for the repair and protection of organism damage. 

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Stem Cells, Exosomes, Regenerative Medicine, Tissue Engineering

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