中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (25): 4727-4734.doi: 10.3969/j.issn.1673-8225.2012.25.034

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

肾功能衰竭患者采用不同血液透析膜材料的生物相容性对比分析

曹 宁   

  1. 解放军沈阳军区总医院血液净化科，辽宁省沈阳市 110016
  • 收稿日期:2012-04-20 修回日期:2012-05-10 出版日期:2012-06-17 发布日期:2013-11-04
  • 作者简介:曹宁☆，女，1970年生，辽宁省辽阳市人，汉族，2010年中国医科大学毕业，博士，副主任医师，主要从事血液透析等血液净化相关技术研究。 cn88860068@ sohu.com

Biocompatibility of different hemodialysis membrane materials used in renal failure patients: A comparative analysis

Cao Ning   

  1. Department of Blood Purification, the General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China
  • Received:2012-04-20 Revised:2012-05-10 Online:2012-06-17 Published:2013-11-04
  • About author:Cao Ning☆, M.D., Associate chief physician, Department of Blood Purification, the General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China cn88860068@ sohu.com

PDF

898

被引次数

35

摘要：

背景：血液透析是急、慢性肾功能衰竭的主要治疗方法，血液透析机是利用半透膜，通过弥散、对流和过滤等程序净化血液，把患者血液中的代谢废物和过多的电解质交换排出体外，透析膜的选择会直接关系到血液透析的治疗效果。
目的：利用CNKI数据库文献检索和深度分析功能，对血液透析膜材料的研究文献资料进行多层次探讨分析。
方法：检索CNKI数据库2002-01/2011-12学术期刊库有关血液透析膜材料的研究文献，采用检索词为“血液透析；透析膜；生物材料”，对文献出版时间、文献数量、学科类别、来源期刊、基金资助、作者分布、研究机构、主要关键词、文献被引频次和下载频次进行相关分析，对检索的文献通过文字和图表的形式作以表述。
结果与结论：共检索到95篇文献参与结果分析。从文献数量上看，2002年发表文献量最多为20篇；《中国血液净化》杂志产出的文献量最多为19篇；从文献的关键词分析可见，血液透析膜主要应用于尿毒症的治疗，透析膜材料的研究重点为生物相容性，包括透析膜对维持性血液透析患者氧化应激、血磷清除的影响等。通过文献计量学方法对CNKI数据库学术期刊库关于血液透析膜材料研究的文献进行分析，可为中国从事血液透析膜材料基础研究和临床实施的工作者提供科研思路和有价值的数据。

关键词: 血液透析, 透析膜, 生物材料, 聚醚砜, 血仿膜, 生物相容性, 血液, 血液相容性, 文献计量

Abstract:

BACKGROUND: Hemodialysis is the main method for the treatment of acute and chronic renal failure; hemodialysis machine can purify the blood through diffusion, convection and filtration procedures by a semi-permeable membrane, and it can excrete the metabolic wastes and excess electrolyte in blood. Selection of the dialysis membrane is closely related with the effectiveness of hemodialysis.
OBJECTIVE: To perform a multilevel analysis on the articles addressing hemodialysis membrane materials using the search and depth analysis capabilities of CNKI database.
METHODS: The CNKI database was used to search articles related to hemodialysis membrane materials from January 2002 to December 2011 with the key words of “hemodialysis, dialysis membrane, biomaterials”. The publishing time, number, subject category, source journals, fund assistance, author distribution, research institution, key words, cited frequency and download frequency of the articles were analyzed. We expressed the articles through text and charts.
RESULTS AND CONCLUSION: A total of 95 articles were included for the analysis. Judging from the number of the articles, there was 20 articles published in 2002; the number of the articles published in Chinese Journal of Blood Purification was up to 19. In view of the key words, hemodialysis membrane was mainly used for the treatment of uremia, and the analysis of the hemodialysis membrane was mainly focused on the biocompatibility of hemodialysis membrane materials, including the effect of dialysis membrane on the oxidative stress and phosphate removal of the patients with maintenance hemodialysis. The articles regarding hemodialysis membrane in CNKI database were analyzed by bibliometric method which could provide the research ideas and valuable data for the workers engaged in the basic research and clinical implementation of hemodialysis membrane materials.

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