中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (25): 4697-4700.doi: 10.3969/j.issn.1673-8225.2012.25.028

• 生物材料基础实验 basic experiments of biomaterials • 上一篇    下一篇

冷冻干燥法制备的β-磷酸三钙多孔生物陶瓷支架

王雪涛1，李 静1，左开慧2，曾宇平2，张保卫1   

  1. 1上海交通大学医学院附属第九人民医院•口腔修复科，上海市口腔医学重点实验室，上海市 200011；
    2中国科学院上海硅酸盐研究所•先进环境材料课题组，上海市200050
  • 收稿日期:2011-11-03 修回日期:2011-12-08 出版日期:2012-06-17 发布日期:2013-11-04
  • 通讯作者: 张保卫，教授，上海交通大学医学院附属第九人民医院?口腔修复科，上海市口腔医学重点实验室，上海市 200011 baoweizhang18@msn.com
  • 作者简介:王雪涛★，男，1985年生，河北省秦皇岛市人，汉族，上海交通大学医学院在读硕士，主要从事口腔修复新材料新技术研究。 wangxuetao198558@126.com
  • 基金资助:

    上海市科学技术委员会资助(08DZ2271100)；上海市重点学科建设项目资助(S30206)；上海市重点(特色)学科建设项目资助(T0202)

Preparation of porous bio-ceramic beta-tricalcium phosphate scaffolds by freeze-drying technique

Wang Xue-tao1, Li Jing1, Zuo Kai-hui2, Zeng Yu-ping2, Zhang Bao-wei1   

  1. 1Department of Dental Restoration, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China;
    2Research Group of Advanced Environmental Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
  • Received:2011-11-03 Revised:2011-12-08 Online:2012-06-17 Published:2013-11-04
  • Contact: Zhang Bao-wei, Professor, Department of Dental Restoration, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China baoweizhang18@ msn.com
  • About author:Wang Xue-tao★, Studying for master’s degree, Department of Dental Restoration, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China wangxuetao198558@126.com

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摘要：

背景：影响冷冻干燥法制备生物陶瓷支架孔形貌和结构的因素有很多，如浆料的固含量，冷冻速率，烧结温度等。
目的：利用冷冻干燥技术结合陶瓷水基浆料，通过改变陶瓷浆料组成，制备不同形貌和孔隙率的β-磷酸三钙多孔生物陶瓷支架，并分析其影响因素。
方法：制备不同固含量和不同聚乙烯醇含量的β-磷酸三钙浆料，经冷冻、干燥及高温烧结得到多孔生物陶瓷支架。应用X射线衍射技术进行物相分析；扫描电镜观察支架截面的微观结构；阿基米德排水法测量支架材料的孔隙率。
结果与结论：X射线衍射图谱显示制备的支架材料各衍射峰强度与位置与β-磷酸三钙标准衍射谱吻合良好；浆料未添加聚乙烯醇时，多孔支架的孔径和孔隙率随着浆料固含量的增加而减小，支架由大的柱状孔和多孔的陶瓷壁组成；当浆料加入聚乙烯醇后，制备的支架由柱状孔转变为三维连通的网状孔，且随聚乙烯醇含量的增加材料的孔隙率升高。说明利用冷冻干燥法，通过控制陶瓷浆料的组成，可制备出形貌和孔隙率可控的生物陶瓷支架。

关键词: 冷冻干燥, β-磷酸三钙, 多孔陶瓷, 聚乙烯醇, 气孔率, 生物材料

Abstract:

BACKGROUND: There are many factors which can influence the microstructures and properties of bio-ceramic scaffolds prepared by the freeze-drying process, such as the slurry solid loading, freezing rate, sintering conditions, and so on.
OBJECTIVE: To prepare bio-ceramic β-tricalcium phosphate (β-TCP) scaffolds with different morphologies and porosities by adjusting the content of the slurries and analyze the influence factors.
METHODS: The β-TCP scaffolds with different morphologies and porosities were prepared, and then bio-ceramic β-TCP scaffolds were obtained through freezing, drying and heating. Phase analysis, microstructure of the section and porosity of bio-ceramic β-TCP scaffolds were detected by X-ray diffraction, scanning electron microscopy and Archimedes drainage method, respectively.
RESULTS AND CONCLUSION: The diffraction peak position of the scaffolds was identical with the standard β-TCP; the scaffolds without polyvinyl alcohol had the macroscopic lamellar pores and porous ceramic walls, and as the solid longing of slurry was increasing, the pore size and the porosity decreased; scaffolds containing polyvinyl alcohol: the lamellar pores gradually changed into the interconnected three-dimensional reticulate pores, and the porosity was improved because of the addition of polyvinyl alcohol. It is indicated the morphology and porosity of the bio-ceramic scaffolds prepared using the freeze-drying process can be controlled by adjusting the content of the slurries.

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