关键词: 癫狂梦醒汤, 血管平滑肌细胞, 增殖细胞核抗原, 血小板源性生长因子B, 动脉粥样硬化

Abstract:

BACKGROUND: Modern clinical studies have shown that Dian Kuang Meng Xing Tang (awaken from the dream of madness decoction) has remedial effects on neurosis, menopausal syndrome, hysteria, dementia and other mental disorders.
OBJECTIVE: To investigate the effects of Dian Kuang Meng Xing Tang on the proliferation of vascular smooth muscle cells in atherosclerosis rabbits.
METHODS: A total of 32 Japan big-ear white rabbits were randomly divided into normal control group, model group, Dian Kuang Meng Xing Tang group and Simvastatin group; the corresponding rabbits in each group were fed with normal diet, high fat diet, high fat diet+ Dian Kuang Meng Xing Tang and high fat diet+Simvastatin for 12 weeks, respectively.
RESULTS AND CONCLUSION: The atherosclerosis model was successfully established with high fat diet. There was a severe pathological lesion of atherosclerosis in the model group; the expression of proliferating cell nuclear antigen and platelet-derived growth factor B was significantly increased, the smooth muscle cells were synthetically changed. The pathological lesion of atherosclerosis in the Dian Kuang Meng Xing Tang group and Simvastatin group were significantly alleviated; the expression of proliferating cell nuclear antigen and platelet-derived growth factor B were significantly reduced; the change of smooth muscle cells were close to “contractile” change. These findings indicate that Dian Kuang Meng Xing Tang has an inhibit effect on the proliferation of smooth muscle cells and can delay the development of atherosclerosis by inhibiting the expression of proliferating cell nuclear antigen and platelet-derived growth factor B.