中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (22): 4023-4026.doi: 10.3969/j.issn.1673-8225.2012.22.008

• 人工假体 artificial prosthesis • 上一篇    下一篇

双髋关节动力髋置换过程中3种麻醉药物的比较★

练克俭，沈佳祚，林达生，李大坤，李  强，张  栋，李  林   

  1. 解放军第一七五医院(厦门大学附属东南医院)全军创伤骨科中心，福建省漳州市 363000
  • 收稿日期:2011-10-24 修回日期:2012-04-24 出版日期:2012-05-27 发布日期:2012-05-27
  • 通讯作者: 沈佳祚，硕士，解放军第一七五医院(厦门大学附属东南医院)全军创伤骨科中心，福建省漳州市 363000 Shenjiazuo09@163.com
  • 作者简介:练克俭★，男，1956年生，江苏省扬州市人，汉族，解放军第二军医大学毕业，硕士，博士生导师，主要从事四肢与脊柱创伤的研究。gkxiaohe@163.com

Three anaesthetic drugs in dynamic hip replacement of double hip joint

Lian Ke-jian, Shen Jia-zuo, Lin Da-sheng, Li Da-kun, Li Qiang, Zhang Dong, Li Lin   

  1. Orthopedic Trauma Center of Chinese PLA, 175 Hospital of Chinese PLA (Southeast Hospital of Xiamen University), Zhangzhou  363000, Fujian Province, China
  • Received:2011-10-24 Revised:2012-04-24 Online:2012-05-27 Published:2012-05-27
  • Contact: Shen Jia-zuo, Master, Orthopedic Trauma Center of Chinese PLA, 175 Hospital of Chinese PLA (Southeast Hospital of Xiamen University), Zhangzhou 363000, Fujian Province, China shenjiazuo09@163.com
  • About author:Lian Ke-jian★, Master, Doctoral supervisor, Orthopedic Trauma Center of Chinese PLA, 175 Hospital of Chinese PLA (Southeast Hospital of Xiamen University), Zhangzhou 363000, Fujian Province, China gkxiaohe@163.com

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摘要：

背景：关于小花猪实验麻醉方面的文献报道较少，且部分文献报道不同麻醉药物在实验中效果不是很理想。
目的：比较双髋关节动力髋置换过程中单药麻醉与不同联合麻醉对小花猪的麻醉效果。
方法：18头小花猪随机分为3组，速眠新Ⅱ单药组颈部肌肉注射速眠新Ⅱ(0.2 mL/kg)，速眠新Ⅱ+戊巴比妥钠组在双侧颈部肌肉分开注射速眠新Ⅱ(0.2 mL/kg)与戊巴比妥钠(15 mg/kg)，速眠新Ⅱ+氯胺酮组于一侧颈部肌肉注射速眠新Ⅱ(0.2 mL/kg)与氯胺酮(10 mg/kg)混合液。麻醉后行双髋关节动力髋置换。
结果与结论：速眠新Ⅱ单药组诱导期较其他2组持续时间长(P < 0.05)，麻醉期较其他2组持续时间短(P < 0.05)；苏醒期各组之间两两比较差异均有显著性意义(P < 0.05)。速眠新Ⅱ+氯胺酮组呼吸频率较其他2组增快(P < 0.05)，速眠新Ⅱ+戊巴比妥钠组心率较其他2组增快(P < 0.05)；速眠新Ⅱ单药组及速眠新Ⅱ+氯胺酮组收缩压较速眠新Ⅱ+戊巴比妥钠组高(P < 0.05)；速眠新Ⅱ+戊巴比妥钠组休克指数较其他2组增高(P < 0.05)。提示联合用药比单药麻醉效果好，速眠新Ⅱ与氯胺酮联合较速眠新Ⅱ与戊巴比妥钠联合麻醉诱导快、维持效果好、安全性高且置换后苏醒快，是比较理想的麻醉方法。

关键词: 速眠新Ⅱ, 髋关节置换, 戊巴比妥钠, 氯胺酮, 麻醉, 猪

Abstract:

BACKGROUND: Literatures and reports about floret pigs’ anesthesia are rare and the effects of these anaesthetic drugs are not perfect.
OBJECTIVE: To compare the effect of single anaesthetic drug and compounded anaesthetic drugs for floret pig during dynamic hip replacement of double hip joint.
METHODS: Research group brought 18 floret pigs, which were randomly divided into three groups. In the Xylazine group,     0.2 mL/kg Xylazine was injected into musculi colli of floret pig. In Xylazine+Pentobarbital group, 0.2 mL/kg Xylazine compounded with 15 mg/kg Pentobarbital were injected into both musculi colli of floret pig. In Xylazine+Ketamine group, 0.2 mL/kg Xylazine mixed with 10 mg/kg Ketamine were injected into one of musculi colli of floret pig. After the anaesthetic took effects, we had the dynamic replacement of double hip.
RESULTS AND CONCLUSION: Induction period of Xylazine group was longer than that of the other two groups (P < 0.05); anaesthesia period of Xylazine group was shorter than that of the other two groups (P < 0.05); there was no significant difference of recovery period among these three groups (P < 0.05). The respiratory rate of Xylazine+Ketamine group was faster than that of the other two groups (P < 0.05); the heart rate of the Xylazine+Pentobarbital group was faster than that of the other two groups  (P < 0.05); the systolic pressure of Xylazine group and Xylazine+Ketamine group was higher than that of Xylazine+Pentobarbital group (P < 0.05); the shock index of Xylazine+Pentobarbital group was higher than that of the other two groups (P < 0.05). We draw a conclusion that combination anesthesia is better than single-agent anesthesia and recommend that Xylazine mixed with Ketamine is better than Xylazine mixed with Pentobarbital as it has shorter time of anesthesia induction, better effect during maintaining and higher security and waking up quickly, and that is the ideal anaesthetic method.

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