中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (19): 3568-3575.doi: 10.3969/j.issn.1673-8225.2012.19.030

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

干细胞移植治疗脊髓损伤的研究与应用★

陈晓春1，张  洋1，李  治1，周郦楠2   

  1. 1沈阳医学院奉天医院骨外科，辽宁省沈阳市110024；2辽宁省职业技术学院形态学教研室，辽宁省沈阳市110010
  • 收稿日期:2012-02-09 修回日期:2012-04-14 出版日期:2012-05-06 发布日期:2012-05-06
  • 作者简介:陈晓春★，男，1967年生，辽宁省沈阳市人，汉族，1996年中国医科大学毕业，硕士，副主任医师，主要从事脊柱外科及关节外科研究。chenxiaochun2012@sina.com

Stem cells in the treatment of spinal cord injury 

Chen Xiao-chun1, Zhang Yang1, Li Zhi1, Zhou Li-nan2   

  1. 1Department of Orthopaedics, Fengtian Hospital of Shenyang Medical College, Shenyang  110024, Liaoning Province, China; 2Teaching Laboratory of Morphology, Occupation and Technology College of Liaoning Province,  Shenyang 110010, Liaoning Province, China
  • Received:2012-02-09 Revised:2012-04-14 Online:2012-05-06 Published:2012-05-06
  • About author:Chen Xiao-chun★, Master, Associate chief physician, Department of Orthopaedics, Fengtian Hospital of Shenyang Medical College, Shenyang 110024, Liaoning Province, China chenxiaochun2012@sina.com

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摘要：

背景：脊髓损伤是中枢神经系统的严重创伤，一些研究认为，干细胞移植可为脊髓损伤治疗提供新的思路。 
目的：利用Scopus数据库文献检索和深度分析功能，对干细胞移植治疗脊髓损伤研究的6年文献资料进行多角度的探讨分析。
设计：文献计量学分析。
资料提取：由第一作者以“neural stem cells (干细胞)，spinal cord injury or spinal injury (脊髓损伤)，cell transplantation (细胞移植)，spinal transection (脊髓横断)”为关键词检索Scopus数据库2006-01/2011-12的相关文献，并将分析结果及资料导出，以文字和图表的形式进行统计和计量分析，描述其分布特征。
入选标准：纳入标准：检索干细胞移植治疗脊髓损伤研究相关的文献。文献类型包括研究原著、综述、会议记录及摘要、快报文章、编辑素材。排除标准：与文章目的无关的文献，大于6年较陈旧的文献，未发表的文章以及需电话追踪和手工检索逐一分析的文献。
主要数据判定指标：以文献的类型、出版时间、发表文献的作者分布、学科类别、机构分布、国家地区分布、来源期刊、及文献被引情况进行相关分析。
结果：Scopus数据库2006/2011收录的文献中共检索到1 080篇干细胞移植治疗脊髓损伤研究相关的文献，研究原著以607篇位居首位，其中有15篇可以确定为经典文献。在时间分布上，文献数量2006/2011总体呈上升趋势，来源出版物呈分散情况。高被引研究原著类文章主要发表在Journal of Neuroscience (《神经科学杂志》)上，目前已发表文献中以美国为主，占全球相关领域发稿量的28.5%。中国在过去6年间在数据库中收录文章总量中排在第2名，共发表212篇相关文章，占全球相关文章的19.6%。 《神经外伤杂志》发表文献量22篇，占全部文献的15.09%。其次为Journal of Neuroscience Research《神经科学研究杂志》21篇。
结论：通过文献计量学方法对来源于Scopus数据库关于干细胞移植治疗脊髓损伤研究的文献进行分析，可为了解该领域的概貌、现状和研究者进一步确定该领域研究的热点难点提供有价值的参考。
 

关键词: 脊髓损伤, 干细胞, 脊髓横断, 细胞移植, 文献计量学

Abstract:

BACKGROUND: Spinal cord injury is a serious trauma to central nervous system. Tissue engineered-cell transplantation provides a new approach for spinal cord injury.
OBJECTIVE: To multivariately analyze the literature on neural stem cells transplantation for the treatment of spinal cord injury through Scopus database.
DESIGN: Bibliometric analysis.
DATA RETRIEVAL: A retrieval was performed for the literature of stem cells transplantation for treating spinal cord injury during 2006-01 and 2011-12 in Scopus. The retrieval results were analyzed, and the trends were described in words and graphics.
SELECTIVE CRITERIA: Articles on stem cells transplantation for the treatment of spinal cord injury include the following types:  (1) peer-reviewed original paper; (2) reviews; (3) meeting notes and abstracts; (4) proceeding papers; (5) editorial materials; (6) letters. Exclusive criteria: (1) Articles unrelated the study of stem cells transplantation for the treatment of spinal cord injury. (2) Articles published before 2006. (3) Articles were not published on journals. (4) Articles which need to be retrieved by phone.
MAIN OUTCOME MEASUREMENTS: Type of document, authors, publication year, journal distribution, discipline distribution, institutional information, citation frequency and country distribution.
RESULTS: A total of 1 080 literatures on stem cells transplantation for the treatment of spinal cord injury were retrieved in Scopus database, in which most of papers were published as original articles (n=607). Fifteen articles were identified as classic literatures. The overall number of literature had an upward trend from 2006 to 2011, and the articles with high citations were published in Journal of Neuroscience. Currently, United States published most literatures, accounting for 28.5% of all the literatures. The second is China, which published 212 literatures, accounting for 19.6% of all the published literatures. 
CONCLUSION: This paper provides a valuable reference for researchers to understand the overview and present situation of this field. 

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