中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (16): 2922-2926.doi: 10.3969/j.issn.1673-8225.2012.16.017

• 材料生物相容性 material biocompatibility • 上一篇    下一篇

氟处理AZ31B生物可降解镁合金材料的细胞相容性*★

姜海英1，闫征斌1, 2，张  照3，艾红军4   

  1. 1大庆市油田总医院口腔科，黑龙江省大庆市  163411；2佳木斯大学口腔医学院，黑龙江省佳木斯市  154007；3广州体育职业技术学院医务所，广东省广州市  510663；4中国医科大学附属口腔医院口腔修复科，辽宁省沈阳市  110002
  • 收稿日期:2011-10-17 修回日期:2011-12-16 出版日期:2012-04-15 发布日期:2012-04-15
  • 通讯作者: 艾红军，博士生导师，教授，中国医科大学附属口腔医院口腔修复科，辽宁省沈阳市 110002
  • 作者简介:艾红军，博士生导师，教授，中国医科大学附属口腔医院口腔修复科，辽宁省沈阳市 110002
  • 基金资助:

    辽宁省自然科学技术基金“AZ31B可降解镁合金在颌骨组织工程中的应用研究(2008079)”。

Cellular compatibility of biodegradable AZ31B magnesium alloys with fluoride treatment

Jiang Hai-ying1, Yan Zheng-bin1,2, Zhang Zhao3, Ai Hong-jun4   

  1. 1Department of  Stomatology, Daqing Oilfield General Hospital, Daqing  163411, Heilongjiang Province, China; 2School of Stomatology, Jiamusi University, Jiamusi  154007, Heilongjiang Province, China; 3Clinic of Guangzhou Sports Vocational Education and Technical College, Guangzhou  510663, Guangdong Province, China; 4Department of Prosthodontics, the Affiliated Stomatology Hospital of China Medical University, Shenyang  110002, Liaoning Province, China
  • Received:2011-10-17 Revised:2011-12-16 Online:2012-04-15 Published:2012-04-15
  • Contact: author: Ai Hong-jun, Doctoral supervisor, Professor, Department of Prosthodontics, the Affiliated Stomatology Hospital of China Medical University, Shenyang 110002, Liaoning Province, China
  • About author:Jiang Hai-ying★, Master, Attending physician, Department of Stomatology, Daqing Oilfield General Hospital, Daqing 163411, Heilongjiang Province, China wanghaoyu2002@ 126.com
  • Supported by:

    Natural Science and Technology Foundation of Liaoning Province, No.2008079*

PDF

425

被引次数

10

摘要：

背景：镁及镁合金作为新型可降解植入材料，具有优异的生物相容性和综合力学性能，但是由于镁及镁合金较差的耐蚀性能，影响到其在临床上的应用。表面氟化处理的AZ31B镁合金是否具有良好的生物相容性尚不清楚。
目的：以诱导的人骨髓间充质干细胞作为检测细胞，评价不同表面氟处理的镁合金材料的细胞相容性。
方法：以诱导的人骨髓间充质干细胞作为检测细胞，取未经氟处理及不同氟处理时间的镁合金材料浸提液进行体外细胞相容性实验，评价不同氟处理的镁合金AZ31B材料的生物相容性。
结果与结论：经氟处理镁合金AZ31B材料与未经氟处理镁合金AZ31B材料相比能显著提高细胞存活率，细胞毒性分级1级，对细胞生长基本无毒性作用。提示经氟处理镁

关键词: 可降解镁合金, 生物医用材料, 骨髓间充质干细胞, AZ31B镁合金, 生物相容性

Abstract:

BACKGROUND: As a new type of biodegradable implant material, magnesium and its alloys have attracted much attention owing to their excellent biocompatibility and comprehensive mechanical properties. However, the clinical application of magnesium and its alloys is affected for their inferior corrosion. It is not confirmed whether AZ31B magnesium alloys with fluoride treatment can exhibit good biocompatibility.
OBJECTIVE: To evaluate the cellular compatibility of magnesium alloy materials with different surface fluoride treatments.
METHODS: The induced human bone marrow mesenchymal cells were taken as the testing cells. The leaching liquor of the magnesium alloy materials with no fluoride treatments and fluoride treatments in different time was extracted for cellular compatibility experiment in vitro. The biocompatibility of AZ31B magnesium alloy materials with different fluoride treatments was evaluated.
RESULTS AND CONCLUSION: This experiment showed that compared with the AZ31B magnesium alloys without fluorine treatments, the cell survival rate of the AZ31B magnesium alloys with fluorine treatments was significantly increased; the toxicity of cells was in grade 1 and there was almost no toxicity to cell growth. These findings suggest that the biocompatibility of AZ31B magnesium alloys with fluoride treatments was superior to that of AZ31B magnesium alloys without fluorine treatments.

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