中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (14): 2645-2647.doi: 10.3969/j.issn.1673-8225.2012.14.036

• 干细胞临床实践 clinical practice of stem cells • 上一篇    下一篇

自体外周血干细胞移植治疗肌萎缩侧索硬化患者9例：短期效果分析★

孙大勇，韩  杰，李雪娇，刘  晶，宋春莉   

  1. 大连医科大学附属第一医院神经内科，辽宁省大连市  116011
  • 收稿日期:2011-07-19 修回日期:2011-09-20 出版日期:2012-04-01 发布日期:2012-04-01
  • 通讯作者: 韩杰，博士，主任医师，大连医科大学附属第一医院神经内科，辽宁省大连市 116011
  • 作者简介:孙大勇★，男，1976年生，辽宁省丹东市人，2003年中国医科大学神经病学专业毕业，硕士，主治医师，主要从事神经重症方面的研究。hastendys@sina.com

Treatment of nine patients with amyotrophic lateral sclerosis by autologous peripheral blood mononuclear cells transplantation: change of short-term effect  

Sun Da-yong, Han Jie, Li Xue-jiao, Liu Jing, Song Chun-li   

  1. Department of Neurology, the First Affiliated Hospital of Dalian Medical University, Dalian  116011, Liaoning Province, China
  • Received:2011-07-19 Revised:2011-09-20 Online:2012-04-01 Published:2012-04-01
  • Contact: Han Jie, Doctor, Chief physician, Department of Neurology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
  • About author:Sun Da-yong★, Master, Attending physician, Department of Neurology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China hastendys@sina.com

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摘要：

背景：目前临床报道已有关于自体骨髓有核细胞、嗅细胞、脐血源干细胞移植治疗肌萎缩侧索硬化的报道。
目的：观察自体外周血干细胞移植治疗9例肌萎缩侧索硬化患者的临床疗效。
方法：采用自身前后对照研究方法，对9例肌萎缩侧索硬化患者自体外周血干细胞移植前和移植后第1，3，6个月神经功能改变(FIM、Norris、Bathel评分)及肌电图改变进行评估。
结果与结论：自体外周血干细胞移植后自我症状改善，神经功能评分显著高于移植前，短期内效果明显，肌电图呈现改善趋势。结果初步表明自体外周血干细胞移植治疗可在一定程度上改善肌萎缩侧索硬化患者神经功能障碍。
关键词：肌萎缩侧索硬化；自体外周血；干细胞移植；神经功能评分；肌电图
缩略语注释：ALS：amyotrophic lateral sclerosis，肌萎缩侧索硬化
doi:10.3969/j.issn.1673-8225.2012.14.036

关键词: 肌萎缩侧索硬化, 自体外周血, 干细胞移植, 神经功能评分, 肌电图

Abstract:

BACKGROUND: At present, there are some clinical reports about the treatment of amyotrophic lateral sclerosis (ALS) by transplantation of autologous bone marrow nucleated cells, olfactory cells and umbilical cord blood-derived stem cells.
OBJECTIVE: To evaluate clinical effect of peripheral blood mononuclear cells transplantation on the treatment of 9 ALS patients.
METHODS: The changes of neurological function (Norris, FIM, Bathel score) and electromyogram (EMG) changes of 9 ALS patients were evaluated by before-after self control study at the 1st, 3rd, 6th months after peripheral blood mononuclear cells transplantation.
RESULTS AND CONCLUSION: After peripheral blood mononuclear cells transplantation, the symptom was improved, neurological scores were significantly higher than pre-transplant, short-term effect was obvious and the EMG showed improvement trend. The results showed that peripheral blood mononuclear cells transplantation has valid short-term effect on improving the neurological dysfunction of ALS patients.

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