中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (6): 1115-1118.doi: 10.3969/j.issn.1673-8225.2012.06.036

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

干细胞移植治疗肝脏疾病的研究进展★

邢秀伟1，2，李建生1   

  1. 1郑州大学第一附属医院消化内科，河南省郑州市450052；2 商丘医学高等专科学校，河南省商丘市476100
  • 收稿日期:2011-11-17 修回日期:2011-12-19 出版日期:2012-02-05 发布日期:2012-02-05
  • 通讯作者: 李建生，博士，教授，主任医师，郑州大学第一附属医院消化内科，河南省郑州市 450052 lijiansheng@medmail.com.cn
  • 作者简介:邢秀伟★，男，1982年生，河南省商丘市人，汉族，郑州大学在读硕士，医师，助理讲师，主要从事肝脏纤维化防治的研究。 sqyzxxw1983@163.com

Advances of stem cells transplantation for hepatic disease

Xing Xiu-wei1, 2, Li Jian-sheng1   

  1. 1Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou  450052, Henan Province, China; 2Shangqiu Medical College, Shangqiu  476100, Henan Province, China
  • Received:2011-11-17 Revised:2011-12-19 Online:2012-02-05 Published:2012-02-05
  • Contact: Li Jian-sheng, Doctor, Professor, Chief physician, Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China lijiansheng@medmail.com.cn
  • About author:Xing Xiu-wei★, Studying for master’s degree, Resident physician, Associate lecturer, Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China; Shangqiu Medical College, Shangqiu 476100, Henan Province, China sqyzxxw1983@163.com

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摘要：

背景：干细胞移植治疗肝病是近年来众多学者研究的热点，干细胞移植的基本理论和临床应用研究都取得了很大的进展。
目的：对干细胞移植的理论依据、干细胞来源、移植方式、实验与临床研究、存在问题及前景进行简要综述。
方法：应用计算机检索中国学术期刊全文数据库(CNKI)和Pubmed数据库中2001-01/2011-11关于干细胞移植治疗肝病的文章，检索主题词“干细胞，移植，肝脏疾病，肝损伤”或“stem cell，transplantation，hepatic disease, hepatic injury”。初检索到192篇文献，据纳入标准保留31篇进行分析、综述。
结果与结论：干细胞来源充足，容易获取，可以体外增殖培养，干细胞移植操作简单，安全性高，尤其自体干细胞移植可完全避免移植排斥反应。但自体干细胞移植肝脏疾病的安全性和有效性尚无公识，需更长期的观察。

关键词: 肝干细胞, 干细胞, 干细胞移植, 自体干细胞移植, 肝脏疾病

Abstract:

BACKGROUND: In the recent years, stem cells transplantation in the treatment of hepatic disease is a hot research spot for many scholars. The research of the basic theory and clinical application about stem cells transplantation has greatly developed. 
OBJECTIVE: To briefly review several aspects of stem cells transplantation, such as the theoretical basis of stem cells transplantation, stem cell sources, ways of transplantation, the experimental and clinical research, the existing problems and prospects.
METHODS: The CNKI database and Pubmed database (during 2001-01/2011-11) were used to search the related articles about stem cells transplantation in the treatment of hepatic disease. The retrieval keywords were “stem cell, transplantation and hepatic disease, hepatic injury” in English and Chinese. There were 192 articles by the initial retrieval. Then 31 articles were remained according to the inclusion criteria. 
RESULTS AND CONCLUSION: Stem cells had adequate sources, and it was easy to obtain. Stem cells could be cultivated and proliferate in vitro. The technology of stem cells transplantation had many advantages, such as the simple operation and high safety. Especially autologous stem cells transplantation could completely avoid transplant rejection. However, the effectiveness and safety of autologous stem cells transplantation for the treatment of hepatic disease was still unclear, a long-term observation was needed to be done.

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