中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (6): 1095-1098.doi: 10.3969/j.issn.1673-8225.2012.06.031

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

脑肿瘤干细胞来源及表面标记物研究的新进展★

邱  实1，2，谭晓华1，黄  辉2   

  1. 1解放军北京军区总医院生物治疗中心，北京市  100068；2解放军第三军医大学，重庆市  400038
  • 收稿日期:2011-09-04 修回日期:2011-12-30 出版日期:2012-02-05 发布日期:2012-02-05
  • 通讯作者: 黄辉，解放军第三军医大学检验系，副教授，重庆市 400038 huanghui@tmmu.edu.cn
  • 作者简介:邱实★，女，1982年生，吉林省长春市人，2006年解放军第三军医大学毕业，硕士，技师，主要从事抑癌基因方面的研究。 loive@sohu.com

Progress in the source and surface markers of brain tumor stem cells

Qiu Shi1, 2, Tan Xiao-hua1, Huang Hui2   

  1. 1Biological Treatment Center, Beijing Military General Hospital of Chinese PLA, Beijing  100068, China; 2Third Military Medical University of Chinese PLA, Chongqing  400038, China
  • Received:2011-09-04 Revised:2011-12-30 Online:2012-02-05 Published:2012-02-05
  • Contact: author: Huang Hui, Associate professor, Third Military Medical University of Chinese PLA, Chongqing 400038, China huanghui@tmmu.edu.cn
  • About author:Qiu Shi★, Master, Technician, Biological Treatment Center, Beijing Military General Hospital of Chinese PLA, Beijing 100068, China; Third Military Medical University of Chinese PLA, Chongqing 400038, China loive@sohu.com

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摘要：

背景：随着对脑肿瘤研究逐步深化，肿瘤干细胞被发现在肿瘤生长、发展、复发和转移中起着不可或缺的独特作用。
目的：综述脑肿瘤干细胞的来源、生物学特性以及研究进展。
方法：应用计算机检索1998-01/2010-01万方数据库相关文章，检索词“脑肿瘤干细胞”，并限定文章语言种类为中文。同时计算机检索1998-01/2010-01 ELSEVIER数据库相关文章，检索词“brain tumor stem cells，BTCTs”，并限定文章语言种类为English。共检索到文献198篇，最终纳入符合标准的文献21篇。
结果与结论：脑肿瘤干细胞可能来源于神经干细胞的突变，具有自我更新和多向分化潜能，CD133和Nestin是目前应用得最多的肿瘤干细胞表面标记物，脑肿瘤干细胞的研究对阐明脑肿瘤发生机制、生物学行为及临床治疗、预后判断都具有重要意义。

关键词: 脑肿瘤干细胞, 神经干细胞, 自我更新, 表面标记, 综述文献

Abstract:

BACKGROUND: With the study of brain tumors, researchers have found that brain tumor stem cells (BTSCs) play an important role in tumor growth, development, recurrence and metastasis.
OBJECTIVE: To review the source, biological characters and research progress of BCTCs.
METHODS: The Wanfang database and ELSEVIER database were used to search the related articles about BTCTs published between January 1998 and January 2010 with the key words of “brain tumor stem cells” in Chinese and “brain tumor stem cells, BTCTs” in English. Totally 198 literatures were screened out, and finally 25 important articles were selected to review according to the inclusion criteria.
RESULTS AND CONCLUSION: BTCTs may originate from mutation of neural stem cells, BTCTs have the character of self-renewal, multi-differentiation potency. CD133 and Nestin is the surface biomarker of BTCTs that has been widely used. Study of BTCTs is helpful to clarify the growth mechanism, biological character, clinical treatment and prognosis analysis of the brain tumor.

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