中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (3): 475-478.doi: 10.3969/j.issn.1673-8225.2012.03.021

• 药物控释材料 drug delivery materials • 上一篇    下一篇

载银硅灰石涂层对变形链球菌的抑制*★

贾  莹1，刘  焱2，秦  波1，王金生2   

  1. 贵阳医学院，1口腔正畸科，2口腔内科，贵州省贵阳市   550002
  • 收稿日期:2011-06-08 修回日期:2011-08-16 出版日期:2012-01-15 发布日期:2012-01-15
  • 通讯作者: 王金生，副主任医师，贵阳医学院口腔内科，贵州省贵阳市 550002
  • 作者简介:贾莹★，女，1975年生，贵州省贵阳市人，汉族，2004年贵阳医学院毕业，硕士，副教授，主要从事口腔正畸学临床及基础研究。 jiayingmed@218@189.cn
  • 基金资助:

    贵州省优秀科技人才省长基金资助项目(黔省专合字(2007)119号)。

Inhibition effect of silver ion-loaded wollastonite coating on streptococcus mutans  

Jia Ying1, Liu Yan2, Qin Bo1, Wang Jin-sheng2   

  1. 1Department of Orthodontics, 2Department of Oral Medicine, Guiyang Medical College, Guiyang  550002, Guizhou Province, China
     
  • Received:2011-06-08 Revised:2011-08-16 Online:2012-01-15 Published:2012-01-15
  • Contact: Wang Jin-sheng, Associate chief physician, Department of Oral Medicine, Guiyang Medical College, Guiyang 550002, Guizhou Province, China
  • About author:Jia Ying★, Master, Associate professor, Department of Orthodontics, Guiyang Medical College, Guiyang 550002, Guizhou Province, China jiayingmed@218@ 189.cn
  • Supported by:

    Governor Foundation for Technological Talent of Guizhou Province, No. 2007-119*

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摘要：

背景：涂层材料本身无抗菌性,带有涂层的植入物在植入体内后也有发生感染的可能。
目的：体外实验评价载银硅灰石涂层对变形链球菌的抑制作用。
方法：用纸片扩散法测定载银硅灰石涂层材料的抑菌环大小，从而评价材料的抑菌性能优劣。
结果与结论：随着硝酸银浓度的提高，涂层载银量增加；5%载银硅石灰组抑菌环持续40 d以上，其最大直径显著大于1%载银硅石灰组抑菌环最大直径及未载银原始硅灰石涂层的抑菌环最大直径(P均< 0 .01)。结果提示，载银硅石灰涂层能缓慢释放出具有抗菌作用的Ag+，从而具有一定的抑菌性。通过加入不同初始浓度的Ag+溶液，可以在一定范围内调节载银硅石灰涂层的抑菌效率和持续时间。

关键词: 银离子, 硅灰石, 涂层, 抗菌性, 变形链球菌。

Abstract:

BACKGROUND: Coating material has no antibacterial. Implants containing coatings may result in infection after implantation   in vivo.
OBJECTIVE: To evaluate the inhibition effect of silver ion-loaded wollastonite coating on streptococcus mutans in vitro.
METHODS: The bacteriostatic annulus of silver ion-loaded wollastonite coating were measured using disc diffusion method in order to evaluate the antibacterial properties of the material.
RESULTS AND CONCLUSION: With the increase of the concentration of nitric acid silver, the silver ion in the coatings was increased. The bacteriostatic annulus of the 5% silver ion-loaded wollastonite group sustained for over 40 days, and the maximum diameter was bigger than those of the 1% silver ion-loaded wollastonite group and the none silver ion-loaded wollastonite group (P < 0.01). It is indicated that the silver ion-loaded wollastonite coating can slowly release Ag+ which can inhibit bacteria. The bacteriostatic efficiency of silver ion-loaded wollastonite coating and its duration time can be regulated in some degree by adding Ag+ solution of different initial concentrations into it.

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