中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (2): 191-200.doi: 10.3969/j.issn.1673-8225.2012.02.001

• 骨组织构建 •    下一篇

成骨细胞的体外培养：来自SCI及NIH基金和德温特专利数据库2008/2010相关文献及数据分析

芮  钢1，金旭红2，郭元利1，胡宝山1
  

  1. 厦门大学附属第一医院，1骨科，
    2检验科，福建省厦门市 361003
  • 收稿日期:2011-11-10 修回日期:2011-12-07 出版日期:2012-01-08 发布日期:2012-01-08
  • 作者简介:芮钢☆，男，1965年生，辽宁省沈阳市人，汉族，2004年中国医科大学毕业，博士，主任医师，硕士生导师，主要从事组织工程和脊柱外科方面研究。 reigang@yahoo.com.cn

In vitro culture of osteoblasts: A bibliometric analysis based on Science Citation Index, NationalInstitutes of Health and Derwent Innovations Index from 2008 to 2010

Rui Gang1, Jin Xu-hong2, Guo Yuan-li1, Hu Bao-shan1   

  1. 1Department ofOrthopaedics, 2Department ofLaboratory Medicine,First AffiliatedHospital of XiamenUniversity, Xiamen361003, FujianProvince, China
  • Received:2011-11-10 Revised:2011-12-07 Online:2012-01-08 Published:2012-01-08
  • About author:Rui Gang☆, Doctor,Chief physician,Master’s supervisor,Department ofOrthopaedics, FirstAffiliated Hospital ofXiamen University,Xiamen 361003,Fujian Province,China reigang@yahoo.com.cn

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摘要：

背景：成骨细胞在骨代谢中发挥了重要作用，其分化成熟、功能活动及凋亡对骨骼形成与矿化的程度都发挥着重要的调控作用。
目的：通过对SCI 数据库、NIH 基金及德温特专利数据库有关成骨细胞体外培养相关文献的计量学分析，得出成骨细胞体外培养的动态研究趋势。
设计：文献计量学分析。资料提取：由第一作者检索SCI数据库, 美国NIH 基金在线查询网站(NIH Research Portfolio Online Reporting Tools)及德温特专利数据库(Derwent Innovations Index)有关成骨细胞的体外培养的文献，基金资助项目，以及专利情况，分析其研究进展。检索时间范围为2008-01/2010-12。数据下载日期为2011-10-18。
入选标准：纳入标准：①同行评议的与成骨细胞体外培养密切相关的研究原著类文献。②与成骨细胞体外培养相关的基金资助项目。③与成骨细胞体外培养相关的专利。

排除标准：①综述，会议记录，会议摘要等文献。②未正式出版的文章。
主要数据的判断指标：①文献发表的作者分布。②时间分布。③地区分布。④机构分布。⑤出版物分布。⑥论文被引频次分布。⑦基金资助与发稿量对比。⑧专利信息。
结果：①SCI数据库2008/2010检索到2 612篇成骨细胞体外培养相关文献，其中研究类文章以2 393篇位居首位。结果分析得出，文献数量呈逐年递增趋势。②有22家核心机构、12种核心期刊和13篇经典文献。《生物医学材料研究杂志-A辑》发文 161篇，处于领先地位，其次为《生物材料》100篇及《骨》77篇。③1 443篇(60.3%)文章获得 2 090种基金资助。成骨细胞体外培养是世界范围学者关注的焦点，每年，美国国立卫生研究院及中国国家自然科学基金都会对成骨细胞研究提供大量的资金资助。④共检索到398项国际专利及11项在中国申请的专利项目，表明中国有关成骨细胞体外培养的专利数量不多。
结论：文献分析显示了成骨细胞的体外培养这一领域的国际发展趋势，为深入研究成骨细胞体外培养的学者提供了可借鉴的参考建议。

关键词: 成骨细胞, 细胞培养, 鉴定, SCI数据库, 文献计量学

Abstract:

BACKGROUND: Osteoblasts play an important role in the regulation of bone metabolism. The bone formation and loss areaffected by osteoblast differentiation and apoptosis.
OBJECTIVE: To identify the global research trends in in vitro culture of osteoblasts from 2008 to 2010 via a bibliometric analysisof Science Citation Index (SCI), National Institutes of Health (NIH) and Derwent Innovations Index.
DESIGN: A bibliometric study.

DATA RETRIEVAL:We performed a bibliometric analysis based on the SCI, NIH and Derwent Innovations Index for dataregarding in vitro culture of osteoblasts from 2008 to 2010. The data were downloaded on October 18, 2011.
SELECTION CRITERIA: ①Articles closely related to in vitro culture of osteoblasts, ②with funding item for in vitro culture ofosteoblasts, and ③with patents related to in vitro culture of osteoblasts were included. Exclusive criteria: ①document types suchas meeting abstracts, reviews, proceedings papers, notes, and letters; ②non-published articles.
MAIN OUTCOME MEASUREMENTS:①Types of documents; ②number of author outputs; ③distribution of output in subjectcategories; ④publication distribution of countries and institutes; ⑤distribution of output in journals; ⑥distribution of citations;⑦funding items; ⑧patents.
RESULTS: ①During 2008 to 2010, 2 612 papers focusing on in vitro culture of osteoblasts were added to the SCI. Articles werethe most frequently used document type. ②The result showed that the amount of literature was annually increased, and therewere 22 core institutes, 12 core journals and 13 classical references. The Journal of Biomedical Materials Research Part Apublished most articles addressing in vitro culture of osteoblasts, followed by Biomaterials and Bone. ③Totally 1 443 articles(60.3%) obtained funding supports from 2 090 funding agencies. ④A total of 398 international patents were searched. All resultsdemonstrated that the topics inosteoblast research are being published around the world.
CONCLUSION: From the analysis of research trends, we put forward suggestions for medical staffs who are currentlyundertaking studies and for those who will be researching and studying in vitro culture of osteoblasts.

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