中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (47): 8773-8776.doi: 10.3969/j.issn.1673-8225.2011.47.009

• 复合支架材料 composite scaffold materials • 上一篇    下一篇

生物蛋白胶复合骨髓间充质干细胞修复兔多层软组织缺损

谢富荣1，林春博1，严冬雪2，杨  渊1   

  1. 1广西骨伤医院，广西壮族自治区南宁市  530012
    2桂林医学院附属医院，广西壮族自治区桂林市  541001
  • 收稿日期:2011-04-07 修回日期:2011-07-08 出版日期:2011-11-19 发布日期:2011-11-19
  • 通讯作者: 杨渊，教授，广西骨伤医院，广西壮族自治区南宁市530012 并列通讯作者：严冬雪，副教授，桂林医学院附属医院，广西壮族自治区桂林市541001
  • 作者简介:谢富荣，男，1971年生，广西壮族自治区桂平市人，汉族，1995年广西中医学院毕业，副主任医师，主要从事骨外科的研究。 Xiefr95628@163.com
  • 基金资助:

    广西科技厅资助项目(桂科攻10124001B-55)，广西科技厅资助项目(桂科攻0816004-15)，广西科技厅资助项目(桂科自0728077)，广西科技厅资助项目(桂科自0832157)，广西科技厅资助项目(桂科攻0592007-1G)。

Fibrin glue combined with bone marrow mesenchymal stem cells to repair multi-layer soft tissue defects in rabbits

Xie Fu-rong1, Lin Chun-bo1, Yan Dong-xue2, Yang Yuan1   

  1. 1Orthopaedic Hospital of Guangxi, Nanning  530012, Guangxi Zhuang Autonomous Region, China
    2Affiliated Hospital of Guilin Medical College, Guilin  541001, Guangxi Zhuang Autonomous Region, China
  • Received:2011-04-07 Revised:2011-07-08 Online:2011-11-19 Published:2011-11-19
  • Contact: Yang Yuan, Professor, Orthopaedic Hospital of Guangxi, Nanning 530012, Guangxi Zhuang Autonomous Region, China Correspondence to: Yan Dong-xue, Associate professor, Affiliated Hospital of Guilin Medical College, Guilin 541001, Guangxi Zhuang Autonomous Region, China
  • About author:Xie Fu-rong, Associate chief physician, Orthopaedic Hospital of Guangxi, Nanning 530012, Guangxi Zhuang Autonomous Region, China Xiefr95628@163.com
  • Supported by:

    grants from Guangxi Science and Technology Bureau, No. 10124001B-55*, 0816004-15*, 0728077*, 0832157*, 0592007-1G*

PDF

311

被引次数

4

摘要：

背景：符合软组织生理结构的生物蛋白胶适合作为修复软组织缺损的载体材料。
目的：观察生物蛋白胶复合骨髓间充质干细胞修复软组织缺损的可行性。
方法：在新西兰大白兔大腿处造成深达肌肉层，直径大于3 cm的软组织缺损。将24只新西兰大白兔随机分为3组，实验组将同种异体来源的骨髓间充质干细胞复合生物蛋白胶注射到软组织缺损处，对照组将生物蛋白胶注射到软组织缺损处，模型组造模后不注射。
结果与结论：术后14，21 d创面收缩率，实验组>对照组>模型组(P < 0.01)；愈合时间，实验组<对照组<模型组(P < 0.01)。结果显示以生物蛋白胶为载体复合骨髓间充质干细胞能快速的修复多层软组织缺损。

关键词: 生物蛋白胶, 骨髓间充质干细胞, 软组织缺损, 创面愈合, 生物材料

Abstract:

BACKGROUND: Fibrin glue meeting the physical structure of the soft tissue is appropriately used as a carrier material to repair soft tissue defects.
OBJECTIVE: To investigate the feasibility of bone marrow mesenchymal stem cells combined with fibrin glue to repair soft tissue defects.
METHODS: Soft tissue defects were made on the deep thigh muscle layer of New Zealand white rabbits with diameter greater than 3 cm. Twenty-four model rabbits were randomly divided into three groups: in experimental group, allogeneic bone marrow mesenchymal stem cells combined with fibrin glue were injected into the soft tissue defects; in control group, the fibrin glue was injected into soft tissue defects of rabbits; in model group, nothing was injected into soft tissue defects of rabbits.
RESULTS AND CONCLUSION: Wound contraction rates at 14 and 21 days after operation were the experimental group > control group > the model group (P < 0.01); the healing time was the experimental group < control group < model group (P < 0.01). The results showed that the fibrin glue combined with bone marrow mesenchymal stem cells can rapidly repair multi-layer soft tissue defects.

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