中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (42): 7851-7854.doi: 10.3969/j.issn.1673-8225.2011.42.015

• 材料力学及表面改性 material mechanics and surface modification • 上一篇    下一篇

聚L乳酸/β-磷酸三钙可吸收材料体内降解过程中的生物力学特性

黄永辉，李大鹏，沈铁城，左  华，田  进，邹  俊   

  1. 江苏大学附属医院骨2科，江苏省镇江市  212001
  • 收稿日期:2011-02-17 修回日期:2011-03-17 出版日期:2011-10-15 发布日期:2011-10-15
  • 作者简介:黄永辉★，男，1966年生，江苏省南通市人，汉族，2004年苏州大学毕业，硕士，硕士生导师，主任医师，主要从事骨科创伤研究。 orthopaedics123@hotmail.com
  • 基金资助:

    镇江市社会发展项目(SH2007018)。

Biomechanical properties of poly-L lactic acid/beta-tricalcium phosphate absorbable materials during degradation in vivo

Huang Yong-hui, Li Da-peng, Shen Tie-cheng, Zuo Hua, Tian Jin, Zou Jun   

  1. Second Department of Orthopedics, the Affiliated Hospital of Jiangsu University, Zhenjiang  212001, Jiangsu Province, China
  • Received:2011-02-17 Revised:2011-03-17 Online:2011-10-15 Published:2011-10-15
  • About author:Huang Yong-hui★, Master, Chief physician, Master’s supervisor, Second Department of Orthopedics, the Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China orthopaedics123@hotmail.com
  • Supported by:

    the Social Development Program of Zhenjiang City, No. SH2007018*

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摘要：

背景：临床应用的金属内固定材料初始弯曲强度及弹性模量约为皮质骨的4倍及20倍，其力学性能不能随骨愈合过程动态变化，出现医学上的“应力遮挡效应”，影响骨愈合且需要二次手术取出。
目的：观察β-磷酸三钙与聚L乳酸复合可吸收内固定材料在动物体内降解后的生物力学特性。
方法：在30只新西兰大白兔腰背部左侧皮下植入聚L乳酸可吸收棒状材料为对照组，右侧植入聚L乳酸/β-磷酸三钙可吸收棒状材料作为实验组。于术前及术后4，8，12，16，24周观察两组材料的弯曲强度、剪切强度及扭转强度。
结果与结论：降解过程中两组材料的弯曲强度、剪切强度及扭转强度随时间的延长呈逐步下降趋势；术后12，16，24周实验组材料弯曲强度均高于对照组材料(P < 0.05)。术后4，8，12，16，24周实验组材料剪切强度均高于对照组材料(P < 0.05)。术后各时间点实验组材料扭转强度均稍高于对照组材料，但差异无显著性意义(P > 0.05)。说明聚L乳酸/β-磷酸三钙可吸收材料的体内降解速度较纯聚L乳酸慢，其力学强度能维持较长时间，可满足松质骨骨折的固定及骨组织愈合的要求。

关键词: 聚L乳酸, &beta, -磷酸三钙, 可吸收, 生物力学, 硬组织植入物

Abstract:

BACKGROUND: The bending strength and elastic modulus of clinical applied metal fixation are 4 and 20 times than that of cortical bone separately. The mechanical properties of the metal cannot change dynamically with bone healing process, so the “stress shielding” emerges and affects the bone healing. Moreover, the metal fixation has to be removed by a second surgery.
OBJECTIVE: To test the mechanical properties of poly-L lactic acid/beta-tricalcium phosphate (PLLA/β-TCP) absorbable fixation materials by in vivo degradation and mechanics experiments.
METHODS: The PLLA/β-TCP were implanted into the right back subcutaneous tissue of 30 New Zealand white rabbits as the experimental group and the PLLA were implanted into the left back subcutaneous tissue as the control group. The rabbits were sacrificed separately at 4, 8, 12, 16, 24 weeks after operation for observation of the mechanical variation of PLLA and PLLA/β-TCP.
RESULTS AND CONCLUSION: The bending strength, shear strength and torsional strength of both PLLA and PLLA/β-TCP decreased with time going on during degradation. The bending strength and shear strength of PLLA/β-TCP were significantly greater than those of PLLA at 12, 16, 24 weeks after operation and at 4, 8, 12, 16, 24 weeks after operation, respectively, (P < 0.05). There was no difference in the torsional strength between the two groups (P > 0.05). The PLLA/β-TCP absorbable materials degrade slower than the pure PLLA. The mechanical strength of PLLA/β-TCP can maintain a longer time to meet the cancellous bone fracture fixation and bone healing requires.

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