中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (42): 7805-7808.doi: 10.3969/j.issn.1673-8225.2011.42.004

• 组织工程骨及软骨材料 tissue-engineered bone and cartilage materials • 上一篇    下一篇

多孔钛修复兔桡骨骨缺损

张红芳1，赵超勇2，范红松2，张  晖1，裴福兴1，王光林1   

  1. 1四川大学华西医院骨科， 四川省成都市610041
    2四川大学国家生物医学材料工程技术研究中心， 四川省成都市 610064
  • 收稿日期:2011-02-09 修回日期:2011-04-13 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 王光林，博士，副教授，四川大学华西医院骨科，四川省成都市 610041
  • 作者简介:张红芳★，男，1976年生，河南省安阳市人，汉族，2011年四川大学毕业，硕士，主治医师，主要从事下肢骨缺损修复研究。 Zhf716@ 163.com
  • 基金资助:

    国家重点基础研究发展计划（973）资助项目（G2005cb623901）；国家重点科技攻关支撑计划资助项目(2006BAI16B01)。

Repairing rabbit radial bone defects by porous titanium

Zhang Hong-fang1, Zhao Chao-yong2, Fan Hong-song2, Zhang Hui1, Pei Fu-xing1, Wang Guang-lin1   

  1. 1Department of Orthopedics, West China Hospital, Sichuan University, Chengdu  610041, Sichuan Province, China
    2National Engineering Research Center for Biomaterials, Sichuan University, Chengdu  610064, Sichuan Province, China
  • Received:2011-02-09 Revised:2011-04-13 Online:2011-10-15 Published:2011-10-15
  • Contact: Wang Gang-lin, Doctor, Associate professor, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • About author:Zhang Hong-fang★, Master, Attending physician, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China Zhf716@163.com
  • Supported by:

    the National Key Basic Research Program of China (973 Program), No. G2005cb623901*; the National Key Science and Technology Research Foundation of China, No. 2006BAI16B01*

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摘要：

背景：已有将多孔钛植入小型骨缺损的报道。
目的：验证多孔钛修复兔桡骨节段性骨缺损的疗效。
方法：成年健康新西兰大白兔 21只，建立双侧桡骨10 mm缺损模型，骨缺损处分别植入多孔钛和多孔羟基磷灰石材料。
结果：材料植入后第4，8，16周取材观察：①4周时多孔钛组和多孔羟基磷灰石组在材料与宿主骨交界处均有少量骨痂形成，第8和16周时孔隙被新生骨组织填充，与自体骨吻合好。②第8，16周时多孔钛组新骨细胞长入量和骨重建效果几乎接近多孔羟基磷灰石组。两组骨面积在新生骨质长入量上差异无显著性意义(P > 0.05)。③第8，16周时多孔钛组的最大承载负荷值明显优于多孔羟基磷灰石组。表明多孔钛支架材料可以促进新骨的形成并有利于节段骨缺损的修复。

关键词: 多孔钛, 多孔羟基磷灰石, 骨缺损, 兔, 修复

Abstract:

BACKGROUND: Usage of porous titanium in the repair of bone defects in animal models has been reported. 
OBJECTIVE: To investigate the therapeutic effects of porous titanium on the recovery of rabbit radial bone defects.
METHODS: A total of healthy 21 New Zealand rabbits were artificially made to be bone defect models by resecting the 1 cm substantial ossea with periosteum of both radii. The left anterior limbs were implanted porous titanium, while the right anterior limbs were implanted porous hydroxyapatite (HA).
RESULTS: ①The gross observation and X-ray results demonstrated that there was a little callus filled in the juncture of materials and autogenous bone both in the left and right anterior limbs 4 weeks after the operation. At 8 and 16 weeks, the materials in the both sides were filled by newly formed bone, and the anastomosis status was good. ②The histology examination showed that mass newly formed bone grew into most pores of both specimens. Along with prolongation of times after operation, the ingrowths of bone cells and effect of bone remodeling in the affected side were nearly as same as the control side at 8 and 16 weeks. The results of histomorphometrical analysis showed that a statistically significant difference was not obtained for % bone area (bone area/gross implant) between the both groups (P > 0.05). ③However, the results of maximum failure load in the affected side were better than those of the control side at 8 and 16 weeks. Osteogenesis can be promoted by porous titanium, which is an appropriate tool to induce the healing of segmental bone defects.

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