中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (41): 7787-7790.doi: 10.3969/j.issn.1673-8225.2011.41.047

• 组织构建临床实践 clinical practice in tissue construction • 上一篇    

外周血白细胞热休克蛋白70 mRNA在太极拳运动后的表达

杨德洪1，魏  勇2   

  1. 1上海应用技术学院体育教育部，上海市 201418
    2上海体育学院运动科学学院，上海市 200438
  • 收稿日期:2011-07-07 修回日期:2011-08-18 出版日期:2011-10-08 发布日期:2011-10-08
  • 作者简介:杨德洪★，男，1975年生，山东省临沂市人，硕士，讲师，主要从事体育教学和运动医学方向的研究。 dehongy@126.com
  • 基金资助:

    上海市教委青年教师基金项目资助(03LQ05)，上海市重点学科建设项目(S30802)。

Heat shock protein 70 mRNA expression in peripheral white blood cells after Taiji-quan exercise

Yang De-hong1, Wei Yong2   

  1. 1Department of Physicial Education, Shanghai Institute of Technology, Shanghai  201418, China
    2School of Sports Science, Shanghai University of Sport, Shanghai 200438, China
  • Received:2011-07-07 Revised:2011-08-18 Online:2011-10-08 Published:2011-10-08
  • About author:Yang De-hong★, Master, Lecturer, Department of Physicial Education, Shanghai Institute of Technology, Shanghai 201418, China dehongy@126.com
  • Supported by:

    a grant from Yong Teachers Foundation of Shanghai Committee of Education, No.03LQ05*; Shanghai Key Subjects Construction Program, No.S30802*

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摘要：

背景：大部分研究显示，太极拳运动有望通过改善机体免疫功能而延缓衰老，但其机制不明。
目的：观察太极拳运动后外周血白细胞热休克蛋白70 mRNA的表达情况。
方法：在健康中老年女性学练太极拳前、练习3个月和6个月时对其外周血白细胞热休克蛋白70 mRNA表达进行实时定量PCR 检测。
结果与结论：经过3个月的太极拳运动干预，中老年妇女外周血白细胞热休克蛋白70 mRNA的表达量与干预前比略增加，但没有明显差异，但干预6个月后表达量下降明显，与干预前和干预3个月的表达量相比差异均有显著性意义。结果初步表明热休克蛋白mRNA表达的改变反映了太极拳健身的效果，而热休克蛋白的分子伴侣作用是太极拳健身效果的可能机制。

关键词: 热休克蛋白, 信使核糖核酸, 太极拳, 白细胞, 免疫功能

Abstract:

BACKGROUND: Several studies have demonstrated that Taiji-quan exercise is promosing to improve organism’s immune function and then postpone aging, but the underlying mechanisms remain poorly understood.
OBJECTIVE: To investigate the heat shock protein 70 (HSP70) expression in peripheral white blood cells after Taiji-quan exercise.
METHODS: The HSP70 mRNA expression was detected by real-time quantitative PCR in peripheral white blood cells of healthy middle-aged and elderly women before, 3 and 6 months after Taiji-Quan exercise.
RESULTS AND CONCLUSION: After 3 months of intensive Taiji-Quan exercise, HSP70 mRNA expression was slightly, but not significantly, increased, compared with before Taiji-Quan exercise. After 6 months of Taiji-Quan exercise, HSP70 mRNA expression was significantly decreased, compared with before exercise and after 3 months of Taiji-Quan exercise. These results suggest that HSP70 mRNA expression can reflect the health benefits of 48-style Taiji-Quan exercise in middle-aged and elderly women and HSP 70 may be the potentioal molecular biological mechanism.

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