中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (10): 1851-1854.doi: 10.3969/j.issn.1673-8225.2011.10.031

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

脐血干细胞移植治疗心肌梗死的作用与机制

杜  丹1，张  明2   

  1. 1辽宁中医药大学附属医院心内2科，辽宁省沈阳市  110032
    2辽宁省金秋医院心内科，辽宁省沈阳市  110032
  • 收稿日期:2010-11-01 修回日期:2010-12-20 出版日期:2011-03-05 发布日期:2011-03-05
  • 通讯作者: 张明，博士生导师，主任医师，辽宁省金秋医院心内科，辽宁省沈阳市110032
  • 作者简介:杜丹★，女，1982年，辽宁省阜新市人，汉族，2008年大连医科大学毕业，硕士，医师，主要从事心血管常见疾病的诊疗工作。 doris346@163.com

Action and mechanism of umbilical cord blood stem cells transplantation for treatment of myocardial infarction 

Du Dan1, Zhang Ming2   

  1. 1Second Department of Cardiology, Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
    2Department of Cardiology, Liaoning Province Jinqiu Hospital, Shenyang  110032, Liaoning Province, China
  • Received:2010-11-01 Revised:2010-12-20 Online:2011-03-05 Published:2011-03-05
  • Contact: Zhang Ming, Doctoral supervisor, Chief physician, Department of Cardiology, Liaoning Province Jinqiu Hospital, Shenyang 110032, Liaoning Province, China
  • About author:Du Dan★, Master, Physician, Second Department of Cardiology, Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China doris346@163.com

PDF

433

被引次数

7

摘要：

背景：多项基础和临床研究表明，干细胞移植可以改善心肌梗死后心力衰竭患者的心脏功能。
目的：总结脐血干细胞移植治疗心肌梗死的的作用与机制。
方法：由第一作者检索2000/2009 PubMed数据库及CNKI、万方数据库有关脐血干细胞移植治疗心肌梗死基础研究方面的文献。
结果与结论：干细胞移植在治疗急性心肌梗死方面已表现出传统治疗方法无法比拟的优势，而目前一系列基础研究证实人脐血干细胞有望成为更为理想的细胞源，但因其尚处于探索性研究阶段，仍有许多问题有待解决，诸如人脐血干细胞的体外分离、培养，最适宜的移植治疗时间，最有利的移植途径，最佳的移植数量，移植细胞的存活率如何，移植后能否分化为心肌细胞，分化程度如何以及其疗效和安全性等。

关键词: 脐血干细胞, 细胞移植, 脐血, 心肌梗死, 心力衰竭

Abstract:

BACKGROUND: Many basic and clinical studies have demonstrated that stem cell transplantation can improve cardiac function in patients with heart failure following myocardial infarction.
OBJECTIVE: To summarize the action and mechanism of umbilical cord blood stem cells (UCBSCs) transplantation for treatment of myocardial infarction.
METHODS: The first author retrieved PubMed Database, CNKI and Wanfang Database for articles of basic research on UCBSCs transplantation for treating myocardial infarction published from 2000 to 2009.
RESULTS AND CONCLUSION: Stem cell transplantation for treating acute myocardial infarction exhibits advantages compared with traditional therapeutic method. A series of present basic researches have confirmed that human UCBSCs can be an ideal cell source, but these studies are in exploratory study stage and many problems should be solved, such as in vitro isolation and culture of human UCBSCs, optimal transplant therapeutic time, favorable transplant pathway, optimal transplant number, survival rate of transplanted cells, differentiation into myocardial cells or not posttransplantation, differentiation degree, therapeutic effects and safety.

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