中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (6): 1103-1106.doi: 10.3969/j.issn.1673-8225.2011.06.034

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

基于乳腺癌干细胞的临床治疗进展

任  远1，李泽桂2   

  1. 解放军第三军医大学，1学员旅四队，2药学院生药学教研室，重庆市   400038
  • 收稿日期:2010-09-03 修回日期:2010-11-01 出版日期:2011-02-05 发布日期:2011-02-05
  • 通讯作者: 李泽桂，博士，教授，解放军第三军医大学药学院生药学教研室，重庆市400038 lizegui@tmmu.edu.cn
  • 作者简介:任远，男，湖南省石门县人，汉族，解放军第三军医大学在读学士，主要从事肿瘤靶向治疗方面的研究。 renyuan364@163.com

Progress in the clinical treatment based on breast cancer stem cells

Ren Yuan1, Li Ze-gui2   

  1. 1The Fourth Student Team, 2Department of Pharmacognosy, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing  400038, China
  • Received:2010-09-03 Revised:2010-11-01 Online:2011-02-05 Published:2011-02-05
  • Contact: Li Ze-gui, Doctor, Professor, Department of Pharmacognosy, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing 400038, China
  • About author:Ren Yuan, The Fourth Student Team, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing 400038, China renyuan364@163.com

PDF

343

被引次数

9

摘要：

背景：肿瘤干细胞在肿瘤的发生、发展、转移和复发等方面发挥着重要的作用。由于常规疗法无法消灭乳腺癌干细胞，故乳腺癌干细胞已被假定为乳腺癌治疗失败的根源。
目的：阐明乳腺癌干细胞的生物学特性及一些乳腺癌靶向治疗药物的疗效，为制定提高乳腺癌患者生存率的治疗方案提供一些建议。
方法：应用计算机检索PubMed数据库2000-01/2010-08有关乳腺癌干细胞的标志物与鉴定、新型药物针对乳腺癌干细胞靶向治疗方面的相关文献，检索词为“breast cancer，cancer stem cells，therapy”，限定文章语言种类为English。检索文献包括临床研究、基础研究及综述类文章，初检得到文献总计203篇，排除重复性研究，保留33篇文献进一步分析。
结果与结论：乳腺癌干细胞是第一个在实体瘤中被鉴定的肿瘤干细胞，人们采用多种策略成功分离出乳腺癌干细胞，对其生物学行为的认识正逐渐深入。乳腺癌干细胞的自我更新、分化等特性受到微环境和许多信号转导通路的调控。如何靶向治疗乳腺癌干细胞，最终根治乳腺癌，正逐渐成为肿瘤靶向治疗研究的一个热点。

关键词: 乳腺癌, 肿瘤干细胞, 放疗耐受性, 化疗耐受性, 靶向治疗

Abstract:

BACKGROUND: Tumor stem cell plays an important role in the occurrence, development, metastasis and recurrence of tumor. However, due to conventional treatment cannot eliminate breast cancer stem cells, breast cancer stem cells have been assumed to be the origin of treatment failure in breast cancer.
OBJECTIVE:To clarify the biological characteristics of breast cancer stem cells and the curative effects of targeted therapy for breast cancer by some drugs targeting, and then provides some advice for developing treatment strategies that may improve survival rate of breast cancer patients.
METHODS: The articles related to the maker of breast cancer stem cells and identification, new drug for the targeting treatment of breast cancer stem cell from PubMed database between January 2000 and August 2010 were retrieved by the computer with the key words of “breast cancer, cancer stem cells, therapy” in English. Literatures were limited to English language. The literatures included clinical research, basic research, and reviews. A total of 204 literatures were obtained from the computer screen, repetitive researches were excluded, and 33 documents of them were involved for further analysis.
RESULTS AND CONCLUSION: Breast cancer stem cells are the first identified cancer stem cells in solid tumor. Breast cancer stem cells have been isolated successfully by many kinds of strategies, and biological characteristics are gradually studied deeply. Self-renewal and differentiation of breast cancer stem cells are regulated by microenvironment and many signaling pathways. Targeted therapy of breast cancer stem cells is gradually becoming the focus of tumor targeted therapy study.

中图分类号: