中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (1): 116-119.doi: 10.3969/j.issn.1673-8225.2011. 01.026

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

肿瘤干细胞的耐药性与耐药机制

保秋萍，李惠民   

  1. 昆明医学院第一附属医院血液科，云南省昆明市   650032
  • 收稿日期:2010-09-05 修回日期:2010-11-10 出版日期:2011-01-01 发布日期:2011-01-01
  • 通讯作者: 李惠民，硕士，主任医师，昆明医学院第一附属医院血液科，云南省昆明市 650032 lihuimin@ medmail.com.cn
  • 作者简介:保秋萍★，女，1984年生，云南省曲靖市人,回族，昆明医学院在读硕士，主要从事肿瘤干细胞的分离和生物学特性的研究。 bqphapyst@163.com

Drug resistance and its mechanisms of cancer stem cells

Bao Qiu-ping, Li Hui-min   

  1. Department of Hematology, First Affiliated Hospital, Kunming Medical College, Kunming  650032, Yunnan Province, China
  • Received:2010-09-05 Revised:2010-11-10 Online:2011-01-01 Published:2011-01-01
  • Contact: Li Hui-min, Master, Chief physician, Department of Hematology, First Affiliated Hospital, Kunming Medical College, Kunming 650032, Yunnan Province, China lihuimin@medmail.com.cn
  • About author:Bao Qiu-ping★, Studying for master’s degree, Department of Hematology, First Affiliated Hospital, Kunming Medical College, Kunming 650032, Yunnan Province, China bqphapyst@163.com

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1884

被引次数

33

摘要：

背景：肿瘤干细胞不仅与肿瘤的多药耐药性有密切的关系，而且有着复杂的多药耐药机制。
目的：对肿瘤干细胞及其耐药性和耐药机制的关系进行总结，为肿瘤的临床治疗提供新的思路。
方法：应用计算机检索FMJS和Pubmed西文数据库检索(2003/2010)，以“cancer stem cell，multiple drug resistance，apoptosis，cell cycle”为检索词；用计算机检索万方数据库(2000/2010)，CNKI数据库(2000-2010)以“肿瘤；肿瘤干细胞；多药耐药性”为关键词。共收集到中文文献56篇，外文文献372篇。排除发表时间早、重复及类似研究，纳入29篇符合标准的文献。
结果与结论：对干细胞的研究帮助人们加深对肿瘤的发生、发展及转移的认识。肿瘤组织中可能存在一小部分肿瘤细胞，与正常干细胞一样具有自我更新和无限增殖的能力，但具有特殊的耐药机制。肿瘤干细胞与肿瘤的发生及治疗关系密切。但针对肿瘤干细胞复杂的多药耐药机制尚有待进一步研究。

关键词: 肿瘤干细胞, 特性, 多药耐药性, 耐药机制, 肿瘤

Abstract:

BACKGROUND: Tumor stem cells not only associate with multidrug resistance in cancer, and have a complex multi-drug resistance
OBJECTIVE: To review correlation of cancer stem cells to drug resistance and resistance mechanisms, and to provide new ideas for clinical therapy of tumor.
METHODS: We searched PubMed Western database and FMJS database (2003-2010) with the key words of “cancer stem cell, multiple drug resistance, apoptosis, cell cycle”. Wanfang database (2000-2010) and CNKI database (2000-2010) were searched by computer with the key words of “tumor, cancer stem cells, multidrug resistance”. A total of 56 Chinese literatures, 372 foreign languages literatures were collected. Published earlier, repeated and similar studies were excluded and 29 literatures were included.
RESULTS AND CONCLUSION: Stem cell research helps people deepen their knowledge of tumor occurrence, development and transfer. Tumor tissues have a small part of tumor cells that have self-renewal and unlimited proliferation ability as normal stem cells, but have a special mechanism of resistance. Tumor stem cells are closely related to tumor occurrence and treatment. However, complex multi-drug resistance of cancer stem cells requires further studies.

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