中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (49): 9298-.doi: 10.3969/j.issn.1673-8225.2010.49.041

• 干细胞学术探讨 • 上一篇    下一篇

miRNA与Notch信号通路在心脏发育中的作用

黄锋，周胜华，潘家义，白中乐，王振河   

  1. 中南大学湘雅二医院心内科，湖南省长沙市 410011
  • 出版日期:2010-12-03 发布日期:2010-12-03
  • 通讯作者: 周胜华，博士，教授，主任医师，博士生导师，中南大学湘雅二医院心内科，湖南省长沙市 410011 zhougqin@21cn.com
  • 作者简介:黄锋☆，男，1979年生，广西壮族自治区灵山县人，汉族，中南大学湘雅二医院在读博士，主治医师，主要从事介入心脏病学研究。 huangfeng3000@126.com

Effects of miRNA and Notch signaling pathway on cardiac development

Huang Feng, Zhou Sheng-hua, Pan Jia-yi, Bai Zhong-le, Wang Zhen-he   

  1. Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha  410011, Hunan Province, China
  • Online:2010-12-03 Published:2010-12-03
  • Contact: Zhou Sheng-hua, Doctor, Professor, Chief physician, Doctoral supervisor, Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China zhougqin@21cn.com
  • About author:Huang Feng☆, Studying for doctorate, Attending physician, Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China huangfeng3000@126.com

PDF

439

被引次数

5

摘要：

背景：miRNA具有调控细胞增殖、分化和生物体生长发育等功能。Notch信号通路在细胞增殖、分化和器官组织发育也起重要作用。miRNA与Notch信号通路分别在心脏发育中的作用及两者之间关系的研究可能会为干细胞移植治疗某些心脏疾病提供新思路。
目的：综述miRNA和Notch信号通路在心脏发育中作用研究的新进展。
方法：应用计算机在Google Scholar、PubMed数据库和ScienceDirect-Home数据库进行检索，英文检索词“miRNA，Notch signaling pathway，cardiac development，stem cells”。
结果与结论：miRNA通过调节靶基因mRNA或抑制翻译而发挥作用，具有调控细胞增殖、分化等生物学功能，在心脏的发育发挥重要作用。Notch信号通路在决定细胞分化方向和心脏正常发育起重要作用。而miRNA-1可抑制Notch信号中Dll1受体表达而促进小鼠胚胎干细胞向心肌细胞分化。深入了解miRNA或Notch信号通路在心脏发育中的机制及两者之间的联系，明确其在调控干细胞分化为心肌细胞的作用，可能会为干细胞移植治疗某些心脏疾病提供新的干预靶点。

关键词: 心脏发育, miRNA, Notch信号通路, 干细胞, 心肌细胞

Abstract:

BACKGROUND: miRNA has the functions of regulating cell proliferation and differentiation, promoting the development of organisms. Notch signaling pathway plays an important role in cell proliferation and differentiation, and the same in organ and organization development. Studies concerning miRNA and Notch signaling pathways in cardiac development and their relationship may provide new ideas in stem cell transplantation for treating certain heart diseases.
OBJECTIVE: To summarize the study progress of the roles that miRNA and Notch signaling pathway playing in cardiac development.
METHODS: We searched literary on the Google Scholar, PubMed database and ScienceDirect-Home website with the key words of “miRNA, Notch signaling pathway, cardiac development, stem cells”.
RESULTS AND CONCLUSION: miRNA has many biological functions in cardiac development such as regulation of cell proliferation and differentiation by adjusting target gene mRNA, or inhibiting its translation. Notch signaling pathway could determine the fate of cells and play an important role in cardiac normal development. Moreover, miRNA could induce embryonic stem cells differentiation into myocardial cells by regulating Dll1 receptor of the Notch signal. Grasping the mechanism and relation of miRNA or Notch signaling pathway playing in cardiac development, and how they induce stem cells differentiation into myocardial cells, could provide us with new intervention targets using stem cells to treat certain heart diseases.

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