中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (47): 8857-8860.doi: 10.3969/j.issn.1673-8225.2010.47.029

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

纳米支架材料在脊髓损伤修复中的应用

于  鹏1，宋展昭2，孙培峰2，陈  君2，鞠  萍2，隋  艳2，刘聘婷2   

  1. 1青岛大学医学院，山东省青岛市 266071；2解放军海军401医院骨一科，山东省青岛市  266071
  • 出版日期:2010-11-19 发布日期:2010-11-19
  • 作者简介:于鹏★，男，1983年生，山东省威海市人，汉族，青岛医学院在读硕士，医师，主要从事脊柱外科方面的研究。 yupeng.v@163.com

Nano-scaffolds applied in repair of spinal cord injury

Yu Peng1, Song Zhan-zhao2, Sun Pei-feng2, Chen Jun2, Ju Ping2, Sui Yan2, Liu Pin-ting2   

  1. 1 Medical College of Qingdao University, Qingdao   266071, Shandong Province, China; 2 First Department of Orthopaedics, The 401 Hospital of Chinese PLA Navy, Qingdao   266071, Shandong Province, China
  • Online:2010-11-19 Published:2010-11-19
  • About author:Yu Peng★, Studying for master’s degree, Physician, Medical College of Qingdao University, Qingdao 266071, Shandong Province, China yupeng.v@163.com

PDF

450

被引次数

13

摘要：

背景：在作为种子细胞载体的组织工程支架材料中，纳米材料因具有利于细胞黏附、增殖等一些独特的效应，使其在脊髓损伤修复的研究中将发挥越来越大的作用。
目的：通过分析和总结近几年采用纳米支架修复脊髓损伤的文献，寻求适合脊髓组织工程的纳米材料及其适用标准。
方法：由第一作者于2010-09应用计算机检索PubMed数据库、万方数据库和维普数据库相关文献。英文资料的检索时间为2000/2009；中文资料的检索时间为2003-01/2010-08。英文检索词为“nanometer scaffold; materials, Spinal cord injury, repair, tissue engineering”；中文检索词为“纳米支架，生物材料，脊髓损伤，修复，组织工程”。 纳入标准：①纳米支架材料、制备工艺及性能的研究。②组织工程修复脊髓损伤的研究。③动物实验及临床应用方面的文献。经过阅读和筛选，共纳入30篇文章进行讨论分析。
结果与结论：与传统的支架材料相比较，纳米支架具有良好的生物降解性能、无免疫原性、可塑性和适宜的力学性能等优异特性，使其在组织工程领域具有十分诱人的应用前景。随着纳米技术的成熟，制备工艺的优化，基因工程的引入，纳米材料安全性能的科学评价等将是纳米级组织工程支架材料未来临床应用的挑战。

关键词: 纳米支架, 生物材料, 脊髓损伤, 修复, 组织工程

Abstract:

BACKGROUND: As the carrier of seed cells in tissue engineering scaffolds, nano-materials is exerting an increasingly important role in repair of spinal cord injury due to unique effects such as favorable cell adhesion and proliferation.
OBJECTIVE: To analyze and summarize the literatures abour spinal cord injury repair using nano-scaffold materials published in recent years, and to search for a suitable nano-material and its applicable standards for spinal cord tissue engineering.
METHODS: A computer-based search was performed in September, 2010 by the first author among PubMed database, Wanfang database and VIP database. English data retrieval time was from 2000 to 2009; Chinese data retrieval time was from January 2003 to August 2010. English key words were “nanometer scaffold; materials; spinal cord injury; repair; tissue engineering”; Chinese key words were “nano-scaffold, biomaterials, spinal cord injury, repair, tissue engineering”. Inclusion criteria: ① nano-scaffold preparation technology and properties. ② tissue engineering repair spinal cord injury. ③ animal experiments and clinical applications. After reading and screening, 30 articles were included in the final analysis.
RESULTS AND CONCLUSION: Compared with the traditional scaffolds, nano-scaffolds have good bio-degradable performance, no immunogenicity, plasticity and excellent mechanical properties, so that the scaffold is potentially applied in the field of tissue engineering. With the development of nanotechnology, the manufacturing technique optimization, the introduction of genetic engineering, and the scientific evaluation of nano-materials’ safety will be the challenges for future clinical application of tissue engineering nano-scaffold materials.

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