中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (40): 7564-7567.doi: 10.3969/j.issn.1673-8225.2010.40.035

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

神经干细胞诱导分化及在运动医学研究领域的应用

张可斌1，刘瑞莲2　   

  1. 1广西钦州学院体育系，广西壮族自治区钦州市  535000；2江西省宜春学院体育学院，江西省宜春市   336000　
  • 出版日期:2010-10-01 发布日期:2010-10-01
  • 通讯作者: 刘瑞莲，硕士，讲师，江西省宜春学院体育学院，江西省宜春市 336000
  • 作者简介:张可斌，男，1963年生，广西壮族自治区钦州市人，汉族，讲师，主要从事体育教学与训练研究。 huayan331@163.com

Application of induction and differentiation of neural stem cells in the field of sports medicine

Zhang Ke-bin1, Liu Rui-lian2　   

  1. 1 Department of Physical Education, Qinzhou University, Qinzhou  535000, Guangxi Zhuang Autonomous Region, China; 2 Physical Education Institute, Yichun University, Yichun  336000, Jiangxi Province, China 　
  • Online:2010-10-01 Published:2010-10-01
  • Contact: Liu Rui-lian, Master, Lecturer, Physical Education Institute, Yichun University, Yichun 336000, Jiangxi Province, China
  • About author:Zhang Ke-bin, Lecturer, Department of Physical Education, Qinzhou University, Qinzhou 535000, Guangxi Zhuang Autonomous Region, China huayan331@163.com

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278

被引次数

3

摘要：

背景：神经干细胞以其所具有的自我更新、多向分化、增殖分裂、对损伤和疾病反应能力强等特点为多种神经系统遗传性疾病和获得性疾病的治疗带来了新的希望。
目的：旨在总结神经干细胞的诱导分化及其机制，探讨其在运动医学研究领域的应用。
方法：应用计算机检索1994/2010 PubMed数据库、中国期刊全文数据库有关神经干细胞、运动性疾病等有关的文献。
结果与结论：目前有关神经干细胞作用于心肌细胞缺血、心肌梗死、神经元损伤、脊髓损伤等相关疾病的研究已经取得了一定的成果，而在运动医学研究领域的应用还有广阔的前景。虽然神经干细胞以其所具有的多样化潜能和自我更新的优势被临床广泛应用，但仍有诸多问题需要进一步解决，如在体外定向诱导分化的神经干细胞及由神经干细胞进一步分化成的神经元或胶质细胞，是否具有特定的功能；体外诱导的神经干细胞如何顺利植入神经组织和定向迁移，在体内它们能否与宿主自体的神经细胞相容并存，能否长期存活和增殖；体外诱导的神经干细胞能否与宿主自体神经细胞整合发挥神经修复作用，以及神经干细胞诱导分化作用于其他运动性伤病修复等方面的研究尚未得到很好的解决。

关键词: 神经干细胞, 诱导分化, 基因调控, 运动医学, 干细胞

Abstract:

BACKGROUND: Neural stem cells (NSCs) with their self-renewal, multi-directional differentiation, proliferation, division, injury and disease on the characteristics of strong reaction with the nervous system for a variety of genetic diseases and acquired diseases have brought new hope.
OBJECTIVE: To summarize NSC differentiation and its mechanisms, and to explore its application to sports medicine research.
METHODS: A computer-based online search was performed in the PubMed database and Chinese journal full-text database for articles published from 1994 to 2010 concerning NSCs and exertional disease.
RESULTS AND CONCLUSION: At present, the role of the NSCs in myocardial ischemia, myocardial infarction, neuronal injury, spinal cord injuries and other related diseases research has achieved some achievements, and the application to sports medicine research has broad prospects. Although the NSCs with the diversity of its potential and have the advantage of self-renewal are extensively used in clinic, there are still many problems to be resolved, such as progenitor cells of NSCs and the NSCs to further differentiate into neurons or glial cells whether it has a specific function; in vitro induced NSCs to be transplanted into neural tissue and directional migration, whether they have compatibility of autologous nerve cells in the body and the host, whether they can survive and proliferate for a long term; in vitro-induced NSCs play a role in nerve repair in the integration of autologous neural cells in the host. The research of induced differentiation of NSCs in other sports injuries has not yet been solved.

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