中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (40): 7535-7538.doi: 10.3969/j.issn.1673-8225.2010.40.028

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

胎盘来源间充质干细胞的生物学特征

张红艳，杨乃龙   

  1. 青岛大学医学院附属医院特需病房，山东省青岛市    266003
  • 出版日期:2010-10-01 发布日期:2010-10-01
  • 通讯作者: 杨乃龙，硕士，主任医师，硕士生导师，博士合作导师，青岛大学医学院附属医院特需病房，山东省青岛市 266003 nailongy@163. com
  • 作者简介:张红艳★，女，1982年生，山东省威海市人，汉族，青岛大学医学院在读硕士，主要从事胎盘间充质干细胞分离培养及诱导分化的研究。 hongyan128@163.com

Biological characteristics of placenta-derived mesenchymal stem cells

Zhang Hong-yan, Yang Nai-long   

  1. Ward of Special Procurement, Hospital Affiliated to Medical College, Qingdao University, Qingdao  266003, Shandong Province, China
  • Online:2010-10-01 Published:2010-10-01
  • Contact: Yang Nai-long, Master, Chief physician, Master’s supervisor, Ward of Special Procurement, Hospital Affiliated to Medical College, Qingdao University, Qingdao 266003, Shandong Province, China nailongy@163.com
  • About author:Zhang Hong-yan★, Studying for master’s degree, Ward of Special Procurement, Hospital Affiliated to Medical College, Qingdao University, Qingdao 266003, Shandong Province, China hongyan128@163.com

PDF

575

被引次数

22

摘要：

背景：近几年间充质干细胞的研究取得了一定的进展，但仍存在来源匮乏及免疫排斥等问题。胎盘间充质干细胞具有诸多优点可能成为间充质干细胞新的来源。
目的：分析总结胎盘间充质干细胞分离、培养及诱导分化的研究进展。
方法：由该论文的研究人员应用计算机检索PubMed数据库1993/2009有关胎盘间充质干细胞性质及诱导分化的文献，检索词“mesenchymal stem cells，placenta”，共检索到180 篇文献，对资料进行初审，排除重复性研究。所选用的41篇文章中，3篇为综述，其余均为临床或基础实验研究。
结果与结论：与研究比较多的骨髓间充质干细胞相比，胎盘间充质干细胞因具有免疫原性低、取材方便、无侵入性操作、无伦理道德限制、分化潜能大、增殖能力强、易于工业化制备等特点，成为再生医学的重要细胞来源和最具临床应用前景的功能干细胞。

关键词: 胎盘, 间充质干细胞, 分离培养, 诱导分化, 综述文献

Abstract:

BACKGROUND: Recently, the study of mesenchymal stem cells (MSCs) makes some progresses, but there are still two major problems: lack of donor and immune rejection. Placenta-derived mesenchymal stem cells (PMSCs) have many advantages and may become a new source of MSCs.
OBJECTIVE: To study the progress in the isolation, culture and induced differentiation of PMSCs.
METHODS: A computer-based online search of Pubmed database was undertaken for the related articles published from 1993 to 2009 with the key words of “mesenchymal stem cells, placenta”. 180 literatures were retrieved and primarily checked. Repeated studies were excluded. Of the 41 selected literatures, 3 were reviews and the others were clinical or basic experiment study.
RESULTS AND CONCLUSION: Compared to research relatively large number of bone marrow mesenchymal stem cells, PMSCs due to a low immunogenicity, facilitated access to materials, non-invasive procedures, no ethical restrictions, large differentiation potential, proliferative ability, easy preparation and other characteristics of industrialization, become a key source of regenerative medicine and functional stem cells with the prospects for clinical application.

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