中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (37): 6959-6962.doi: 10.3969/j.issn.1673-8225.2010.37.028

• 组织构建基础实验 basic experiments in tissue construction • 上一篇    下一篇

雌性大鼠雌激素和骨密度变化对长期中小强度游泳运动的影响

阮彩莲1，阮红斌2，艾  宁2   

  1. 1延安大学医学院解剖教研室，陕西省延安市 716000；2延安市中医医院西药房，陕西省延安市 716000   
  • 出版日期:2010-09-10 发布日期:2010-09-10
  • 作者简介:阮彩莲★，女，1974年生，硕士，陕西省延安市人，汉族，2008年西安体育学院毕业，讲师，主要从事基础解剖学研究。 rcl1157@163.com

Changes of estrogen level and bone mineral density in female rats during long-term low and medium intensity swimming movements

Ruan Cai-lian1, Ruan Hong-bin2, Ai Ning2   

  1. 1 Department of Anatomy, College of Medicine, Yan’an University, Yan’ an   716000, Shaanxi Province, China; 2 Pharmacy, Yan’an Hospital of Traditional Chinese Medicine, Yan’an   716000, Shaanxi Province, China 
  • Online:2010-09-10 Published:2010-09-10
  • About author:Ruan Cai-lian★, Master, Lecturer, Department of Anatomy, College of Medicine, Yan’ an University, Yan’ an 716000, Shaanxi Province, China rcl1157@163.com

PDF

322

被引次数

8

摘要：

背景：有研究表明长期进行有氧运动可以引起女性雌激素和骨质成分的改变，但其机制不明。
目的：观察长期中小强度游泳运动对SD雌性大鼠雌激素及骨密度的影响。
方法：将SD大鼠随机分成对照组，游泳组Ⅰ和Ⅱ，两个游泳组从第1周开始均采用递增负荷游泳运动模式，游泳组Ⅰ以每次运动60 min的负荷游泳4周；游泳组Ⅱ以每次运动60 min的负荷游泳7周。对照组不做任何训练干预。两个游泳组每次游泳1 h后，均用电子显微镜动态观察大鼠阴道脱落细胞的数量和形态变化。训练结束后，用放射免疫法测定各组大鼠的雌激素水平，用双能X射线骨密度吸收仪测骨密度。
结果与结论：与对照组比较，游泳组Ⅱ大鼠阴道底层细胞的数量逐周增多，第7周最多(P < 0.01)。游泳组Ⅱ大鼠血清雌二醇、孕酮和血睾酮明显升高 (P < 0.01)。游泳组Ⅰ腰椎及股骨的骨密度均高于对照组 (P < 0.05)。游泳组Ⅱ的腰椎及股骨的骨密度均高于游泳组Ⅰ(P < 0.05，P < 0.01)。结果提示，长期中小负荷游泳运动可提高大鼠的骨密度和雌激素水平。

关键词: 游泳运动, 有氧运动, 雌激素, 骨密度, 骨质疏松, 组织工程

Abstract:

BACKGROUND: Researches have showed that long term aerobic exercises can lead to component changes of female estrogen and bone mineral density, and the mechanism is still unclear.
OBJECTIVE: To observe the influence of long-term low and medium intensity swimming movements on estrogen level and bone mineral density of female SD rats.
METHODS: Forty SD rats were randomly divided into swimming group Ⅰ, group Ⅱ and control group. The two swimming groups began to swim in a graded exercise testing mode from the first week. The swimming movements lasted for 4 weeks and 7 weeks respectively for group Ⅰand group Ⅱ. No exercises were performed in the control group. After 1-hour swimming every time, the number and form of desquamated vagina cells in both groups were dynamically observed under electron microscope. 
RESULTS AND CONCLUSION: Compared with the control group, the number of cells at the bottom of the rats’ vagina of group Ⅱ increased week by week, and reached the peak at the seventh week (P < 0.01). Serum estradiol, progesterone and testosterone levels of groupⅡ obviously increased (P < 0.01). Bone mineral densities of the lumbar vertebra and femur in group Ⅰwere higher than those in the control group (P < 0.05), but lower than those in group Ⅱ (P < 0.05, P < 0.01). The results indicated that long-term low and medium intensity swimming movements can promote the bone mineral density and estrogen level of female rats.

中图分类号: