中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (23): 4351-4354.doi: 10.3969/j.issn.1673-8225.2010.23.038

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

Notch信号转导通路在神经修复与再生中的激活效应

王  凯1，赵  斌1，王栓科1，王  娜2   

  1. 1兰州大学第二医院骨科，甘肃省兰州市  730000； 
    2兰州大学第一医院肿瘤科，甘肃省兰州市  730000；
  • 出版日期:2010-06-04 发布日期:2010-06-04
  • 通讯作者: 赵 斌，副主任医师，兰州大学第二医院骨科，甘肃省兰州市 730000 zhaobin05@ 126.com
  • 作者简介:王 凯,男，1981年生，甘肃省兰州市人，兰州大学在读硕士，主要从事脊柱脊髓损伤方面的研究。 56966186@qq. com
  • 基金资助:

    甘肃省自然科学研究基金计划(096RJZA078)

Role of Notch signal transduction pathway in never repair and regeneration

Wang Kai1, Zhao Bin1, Wang Shuan-ke1, Wang Na2   

  1. 1Department of Orthopaedics, Second Hospital of Lanzhou University, Lanzhou  730000, Gansu Province, China;
    2Department of Oncology, First Hospital of Lanzhou University, Lanzhou  730000, Gansu Province, China
  • Online:2010-06-04 Published:2010-06-04
  • Contact: Zhao Bin, Associate chief physician, Department of Orthopaedics, Second Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China zhaobin05@126.com
  • About author:Wang Kai, Studying for master’s degree, Department of Orthopaedics, Second Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China 56966186@qq.com
  • Supported by:

    the Natural Science Foundation of Gansu Province, No. 096RJZA078*

PDF

631

被引次数

6

摘要：

背景：近年来发现神经干细胞可以通过对等分裂方式分化为功能神经细胞，从而使损伤的神经细胞功能得到恢复，而Notch信号转导通路对神经细胞发育成一系列的神经元和胶质细胞具有允许和决定作用。
目的：文章主要对Notch的结构、调节机制、影响因素及对神经细胞的作用与影响进行了综合分析。
方法：应用计算机检索CNKI和PubMed数据库中有关信号途径与神将干细胞分化发育和脊髓损伤有关的文章，检索关键词“Notch，神经细胞，神经修复，神经再生”或“signal transduction, NSC, SCI, Notch”。初检得到430篇文献，最终纳入有代表性的31篇文章进行综述。
结果与结论：文章主要讨论了Notch在神经修复与再生中的重要地位，它可以选择性激活体外的多能神经干细胞和体内胚胎前脑的放射状神经胶质，而且，在神经胶质发生过程中激活是星形神经胶质发育所必需的，并对其他功能细胞的发育、生长及凋亡起着重要的调控作用。

关键词: 信号转导通路, Notch, 神经细胞, 神经修复与再生, 干细胞

Abstract:

BACKGROUND: Neural stem cells differentiate into functional neurocytes though equity cleavage, thereby recovery function of damaged cells. Notch signal transduction determines neurons differentiating into neurons and gliocytes.
OBJECTIVE: To summarize Notch structure, adjusting mechanism, influence factors, and effect on neurocytes.
METHODS: Articles addressing signal transduction, differentiation and development of neural stem cells, and spinal cord injury were retrieved from CNKI and PubMed database with the key words of “Notch, neurocyte, neural repair, neural regeneration” or “signal transduction, NSC, SCI, Notch”. A total of 430 articles were retrieved, and 31 ones were included in the final analysis.
RESULTS AND CONCLUSION: Effect of Notch on nerve repair and regeneration were mainly discussed. The Notch could selectively activate multi-functional neural stem cells in vitro and embryonic prosencephalic radiated neuroglia in vivo; moreover, activation is necessary for star-like neuroglia during the development, because it played an important role in adjusting development, growth, and apoptosis of other functional cells.

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