中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (23): 4333-4336.doi: 10.3969/j.issn.1673-8225.2010.23.034

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

急性肾小管坏死治疗的新方向：外源性间充质干细胞及其促修复机制

刘 琳1,2，蔡广研1，张 利1   

  1. 1解放军总医院全军肾脏病研究所暨重点实验室，北京市  100853； 
    2南开大学医学院，天津市  300071
  • 出版日期:2010-06-04 发布日期:2010-06-04
  • 通讯作者: 蔡广研，主任医师，教授，解放军总医院全军肾脏病研究所暨重点实验室，北京市 100853 caiguangyan@ sina.com
  • 作者简介:刘 琳，女，1984年生，内蒙古自治区呼和浩特市人，蒙古族，2010年南开大学毕业，硕士，主要从事肾脏病的研究。 yummylynn@ 126.com
  • 基金资助:

    全军十一五医药卫生科研项目(06Q065)

New direction of acute tubular necrosis treatment: Mechanism of promoting kidney repair by exogenous mesenchymal stem cells

Liu Lin1,2, Cai Guang-yan1, Zhang Li1   

  1. 1Kidney Disease Institute, General Hospital of Chinese PLA, i.e., Key Laboratory, Beijing  100853, China;
    2Medical College, Nankai University, Tianjin  300071, China
  • Online:2010-06-04 Published:2010-06-04
  • Contact: Cai Guang-yan, Chief physician, Professor, Kidney Disease Institute, General Hospital of Chinese PLA, i.e., Key Laboratory, Beijing 100853, China caiguangyan@sina. com
  • About author:Liu Lin, Master, Kidney Disease Institute, General Hospital of Chinese PLA, i.e., Key Laboratory, Beijing 100853, China; Medical College, Nankai University, Tianjin 300071, China yummylynn@126. com
  • Supported by:

    the Scientific Research Program of Medical Science of Chinese PLA during the 11th Five-Year Plan Period, No. 06Q065*

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摘要：

背景：间充质干细胞以其分化潜能大、分泌功能强以及获取简便、易于培养、性质稳定等特点，成为近年来组织修复再生领域的研究热点。在肾脏病治疗研究中，大量动物实验证实间充质干细胞能够显著促进急性肾小管坏死的修复。同时，学者们也在不断探究其作用机制。
目的：综述目前外源性间充质干细胞移植促进急性肾小管坏死修复的动物研究成果，并通过分析所搜集的各项体内、体外研究结果阐明目前对于外源性间充质干细胞促进急性肾小管坏死修复作用机制的认识。
方法：应用计算机检索2004-01/2009-07 PubMed数据库相关文章，检索词为“mesenchymal stem cell，acute tubular necrosis，acute kidney injury，immune，cytokine，renal progenitor cells，tubular epithelial cells”，并限定文章语言种类为English；同时手工检索《中国肾脏病学》。计算机初检得到306篇文献，手工检索得到3篇文献，检索文献数量总计309篇，37篇文献符合纳入标准。
结果与结论：在肾脏病研究领域，大量动物实验证实外源性间充质干细胞移植能够促进急性肾小管坏死的修复，为急性肾小管坏死的治疗提供了新方向。目前对于其机制的了解主要包括：①直接分化为肾小管上皮细胞参与组织重构。②在内分泌、旁分泌作用的基础上通过调节免疫和激活肾内细胞等作用促进肾脏修复。

关键词: 急性肾小管坏死, 间充质干细胞, 修复, 作用机制, 综述文献

Abstract:

BACKGROUND: Mesenchymal stem cells have become a spotlight in the field of tissue repair and regeneration, due to its extensive capacity of differentiation and secretion as well as simple collection, culture advantages and stable characteristics. In the field of nephrology, the ability of exogenous mesenchymal stem cells to promote the repair process following acute tubular necrosis has been proved in multiple animal researches. Meanwhile, researchers are making efforts to explore the exact mechanism.

OBJECTIVE: To review current animal researches about exogenous mesenchymal stem cells on promoting the repair process of acute tubular necrosis, and to analyze the results to further elucidate the mechanism of this promoting effect.

METHODS: We checked PubMed database about the related articles published from January 2004 to July 2009 on computer with key words of “mesenchymal stem cell, acute tubular necrosis, acute kidney injury, immune, cytokine, renal progenitor cells, tubular epithelial cells”. The language was limited to English. Simultaneously, we also checked the book Chinese Journal of Nephrology by hand. A total of 309 articles have been attained, with 306 from computer and 3 from the book, and 37 articles were consistent with inclusion criteria.

RESULTS AND CONCLUSION: In the field of nephrology, a great number of animal researches have proved that exogenous mesenchymal stem cells could promote the repair process after acute tubular necrosis, which provides a prospective effect for the treatment of acute tubular necrosis. Up to now, the possible mechanisms of this process include: ①mesenchymal stem cells differentiate into tubular epithelial cells directly to renew the damaged structure. ②Mesenchymal stem cells modulate immune system and activate intrinsic kidney cells via endocrine or paracrine to help repair the injured tissue.

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