中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (23): 4329-4342.doi: 10.3969/j.issn.1673-8225.2010.23.033

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

骨髓间充质干细胞在肾脏疾病中的应用

赵红梅1，胡 祥2，李 芳1，贾丹兵1   

  1. 1解放军第二一一医院肾内科，黑龙江省哈尔滨市   150086；
    2深圳市北科细胞工程研究所，广东省深圳市   518057
  • 出版日期:2010-06-04 发布日期:2010-06-04
  • 通讯作者: 李 芳，博士，主任医师，解放军第二一一医院，黑龙江省哈尔滨市 150086 weizhaohongmei@163.com
  • 作者简介:赵红梅，女，1976年生，黑龙江省依安县人，汉族，1999年黑龙江中医药大学毕业，硕士，主治医师，主要从事肾脏疾病研究。

Bone marrow mesenchymal stem cells transplantation for kidney diseases  

Zhao Hong-mei1, Hu Xiang2, Li Fang1, Jia Dan-bing1   

  1. 1Department of Nephrology, the 211 Hospital of Chinese PLA, Harbin   150086, Heilongjiang Province, China;
    2Shenzhen Beike Cells Engineering Research Institute, Shenzhen  518057, Guangdong Province, China
  • Online:2010-06-04 Published:2010-06-04
  • Contact: Li Fang, Doctor, Chief physician, Department of Nephrology, the 211 Hospital of Chinese PLA, Harbin 150086, Heilongjiang Province, China weizhaohongmei@ 163.com
  • About author:Zhao Hong-mei, Master, Attending physician, Department of Nephrology, the 211 Hospital of Chinese PLA, Harbin 150086, Heilongjiang Province, China

被引次数

18

摘要：

背景：研究证明，移植间充质干细胞可以修复受损肾脏并可分化为肾小管上皮细胞,从而恢复肾脏的组织结构和功能。
目的：综合分析骨髓间充质干细胞对肾脏疾病的治疗作用及其作用机制。
方法：应用计算机检索中英文科技期刊数据库1999-01/2009-12期间与间充质干细胞移植和肾脏疾病防治相关的文献，检索词“间充质干细胞、肾脏疾病”，限定文章语言种类为中英文。对资料进行初审，并查看每篇文献后的引文，文献所述内容应与间充质干细胞移植、肾脏疾病相关，且以近5年发表在较权威杂志者优先。排除重复性文章及Meta分析类文章。
结果与结论：骨髓间充质干细胞移植可以促进多种肾脏疾病的恢复，通过向肾小球和肾小管细胞分化及促进肾脏分泌等机制对肾脏疾病起到治疗作用。骨髓间充质干细胞用于治疗肾脏疾病多停留在试验阶段，研究对象主要是动物模型，临床研究开展不多，主要在IgA肾病及一些继发性肾脏疾病，如狼疮性肾炎、淀粉养变肾损害、转移性肾细胞癌等中应用，且大多都处于摸索阶段，有很多问题有待解决。

关键词: 肾病, 间充质干细胞, 机制, 动物模型, 骨髓间充质干细胞

Abstract:

BACKGROUND: Previous research has proved that bone marrow mesenchymal stem cells (MSCs) transplantation can repair injured kidney and the transplanted MSCs can differentiate into renal tubular epithelial cells, and thereby recovere the structure and function of kidney.

OBJECTIVE: To analyze the application and the potential mechanisms of MSCs for treating kidney disease.

METHODS: A computer-based search of Chinese and English Scientific and Technological Periodical Databases was performed to identify the articles about the correlation between MSCs and kidney disease, with the key words of “bone marrow mesenchymal stem cells, kidney disease”, and the language was limited to Chinese and English. After the first round of selection, the quotations of each literature were also reviewed, and those related to MSC transplantation and kidney disease and published in authoritative journals within 5 years were included. But repetitive articles and Meta analysis were excluded.

RESULTS AND CONCLUSION: Transplantation of MSCs could promote the recovery of renal function by differentiating into glomerulus and tubular cells and it could also promote renal secretion. However, MSC transplantation for treating kidney disease still stayed at clinical test level, and animal models were the major research subjects. Moreover, clinical application for treating IgA kidney disease and secondary kidney disease, such as lupus nephritis, renal amyloidosis, and metastatic renal cell carcinoma, needs to be further studied.

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