中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (20): 3744-3747.doi: 10.3969/j.issn.1673-8225.2010.20.032

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

骨骼肌细胞中热休克蛋白72表达与运动及肌肉损伤

卢文彪   

  1. 韶关学院体育学院，广东省韶关市 512005
  • 出版日期:2010-05-14 发布日期:2010-05-14
  • 作者简介:卢文彪，男，1971年生，江西省抚州市人，汉族， 2003年华南师范大学毕业，硕士，讲师，主要从事运动生理学的教学和研究。 wenbiaolu@163.com

Heat shock protein 72 expression in skeletal muscle cells and exercise as well as muscle injury

Lu Wen-biao   

  1. College of Physical Education, Shaoguan University, Shaoguan  512005, Guangdong Province, China
  • Online:2010-05-14 Published:2010-05-14
  • About author:Lu Wen-biao, Master, Lecturer, College of Physical Education, Shaoguan University, Shaoguan 512005, Guangdong Province, China wenbiaolu@163.com

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497

被引次数

3

摘要：

背景：运动应激诱导的骨骼肌细胞中热休克蛋白72的表达与肌肉损伤程度大小有关。
目的：综述骨骼肌细胞中热休克蛋白72在运动中的表达及其与运动的相互关系，并对其在运动医学领域中潜在的研究价值进行了探讨。
方法：应用计算机检索国家科技文献图书中心1990-01/2009-10的相关文献，检索词“heat shock protein 72， skeletal muscle”，限定文章语言种类为“English”；同时计算机检索万方数据库1994-01/2009-10的相关文献，检索词“热休克蛋白72，骨骼肌”，限定文章语言种类为中文。并通过手工检索相关文献。纳入具有原创性，论点论据可靠，观点明确，分析全面，文献主题内容与此论文联系密切的文章。排除实验设计不合理的文章及观点模糊的综述。
结果与结论：热休克蛋白广泛存在于生物界，对机体具有保护作用。运动应激诱导骨骼肌细胞中热休克蛋白72mRNA 的表达及热休克蛋白72的合成与运动负荷量、运动强度和持续时间密切相关，尤其是运动强度。热休克蛋白72在骨骼肌细胞受到过强应激时，其合成量非但没有减弱相反明显增加。作为肌肉应激指标，热休克蛋白72提供了运动引起的骨骼肌细胞功能变化的重要信息，对预防过度训练和确定随后的训练计划可能是一个很好的量化指标。

关键词: 热休克蛋白72, 骨骼肌细胞, 应激, 运动, 肌肉肌腱组织工程, 综述文献

Abstract:

BACKGROUND: Heat shock protein 72 expression in skeletal muscle cells induced by exercise stress has correlated with muscular injury.
OBJECTIVE: To summarize the correlation between heat shock protein 72 expression in skeletal muscle cells and exercise, and to explore the potential value in sports medicine.
METHODS: A computer-based online search was conducted in National Scientific & Technical Library Document Center with the key words of “heat shock protein 72, skeletal muscle” in both Chinese and English from January 1990 to October 2009. Relevant data were also searched in Wanfang database with the key word of heat shock protein 72 in Chinese from January 1994 to October 2009. Articles addressing originality, reliability, identification, general analysis, and high correlation were included; however, articles due to unconscionable design and unclear review were excluded.
RESULTS AND CONCLUSION: The heat shock protein existed in the organism widely and had protective function on body. Exercise stress which induced heat shock protein 72 mRNA expression and heat shock protein 72 synthesis was highly correlated with exercise loading dose, intension, and duration, in particular exercise intension. When heat shock protein 72 was strongly stimulated by exercise stress, the synthetic dose was increased significantly. As a muscle stress indicator, heat shock protein 72 provided important evidence for functional changes of skeletal muscle cells induced by exercise; on the other hand, it was also an ideal indicator for preventing overtraining and training plan.

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