中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (20): 3682-3685.doi: 10.3969/j.issn.1673-8225.2010.20.017

• 组织构建与中医药 tissue construction and traditional Chinese medicine • 上一篇    下一篇

海桐皮汤熏洗治疗膝骨性关节炎：与扶他林乳剂的比较

吴广文1，张 翼2，林木南3，洪昆达2，吴明霞2，刘献祥1   

  1. 1福建中西医结合研究院，福建省福州市  350108； 
    2福建省第二人民医院，福建省福州市  350003；
    3解放军南京军区福州总医院，福建省福州市  350001
  • 出版日期:2010-05-14 发布日期:2010-05-14
  • 通讯作者: 刘献祥，博士，教授，福建中西医结合研究院，福建省福州市 350108 liuxianxiang@163.com
  • 作者简介:吴广文，男，1982年生，福建省泉州市人，汉族，2009年福建中医学院毕业，硕士，研究实习员，主要从事骨性关节炎方面的研究。 Wgw013020@163.com
  • 基金资助:

    陈可冀中西医结合发展基金(CKJ2007018)

Treatment of knee osteoarthritis using steam-wash therapy with Haitongpi decoction: In comparison with Votalin Emulgel  

Wu Guang-wen1, Zhang Yi2, Lin Mu-nan3, Hong Kun-da2, Wu Ming-xia2, Liu Xian-xiang1   

  1. 1Fujian Academy of Integrative Medicine, Fuzhou  350108, Fujian Province, China;
    2Second People’s Hospital of Fujian Province, Fuzhou  350003, Fujian Province, China;
    3Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA, Fuzhou  350001, Fujian Province, China
  • Online:2010-05-14 Published:2010-05-14
  • Contact: Liu Xian-xiang, Doctor, Professor, Fujian Academy of Integrative Medicine, Fuzhou 350108, Fujian Province, China liuxianxiang@163.com
  • About author:Wu Guang-wen, Master, Investigator, Fujian Academy of Integrative Medicine, Fuzhou 350108, Fujian Province, China Wgw013020@163.com
  • Supported by:

    Chen Ke-ji Developing Foundation for Integrated Traditional Chinese and Western Medicine, No. CKJ2007018*

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摘要：

背景：膝骨性关节炎是由于风寒湿邪痹阻关节、经络所致，而海桐皮汤具有使气血通畅，经络舒展，肿胀消退之功效。

目的：观察海桐皮汤熏洗治疗膝骨性关节炎的临床疗效。

方法：将符合纳入标准的110例膝骨性关节炎患者按就诊先后顺序随机分为熏洗组与对照组，其中熏洗组55例，对照组55例。根据设计好的症状体征评分标准，计算治疗前患者的症状体征积分；分别予以海桐皮汤熏洗及扶他林乳剂外用治疗，1个月后比较治疗前后患者的临床症状、体征、疼痛积分的变化及两治疗组在不良反应、失访率和复发率等的差异。

结果与结论：两种药物在改善患者症状体征方面均具有良好疗效，海桐皮汤熏洗疗效[(控显率57.45%，总有效率95.74%)]优于外用扶他林乳剂[(控显率37.0%，总有效率78.3%)]。两组治疗后疼痛积分较治疗前减少(P < 0.01或0.05)；熏洗组明显优于对照组(P < 0.01)。熏洗组有3例患者出现皮疹、红斑等过敏现象，对照组中2例患者也出现上述过敏现象，均在休息一两天后缓解，两组不良反应差异无显著性意义；熏洗组复发率低于对照组。结果证实，海桐皮汤熏洗对治疗早、中期膝骨性关节炎疗效确切，疗效优于外用扶他林乳剂，且复发率低于对照组。

关键词: 海桐皮汤, 熏洗, 骨性关节炎, 临床研究, 症状体征积分, 骨组织工程

Abstract:

BACKGROUND: The knee osteoarthritis is caused by the wind, coldness, dampness and evil in joints and meridians. While, steam-wash therapy with Haitongpi decoction has the function of promoting blood flow, spreading out meridian and subsiding intumesce.

OBJECTIVE: To observe the clinical curative effect of steam-wash therapy with Haitongpi decoction for knee osteoarthritis.

METHODS: Based on the selection criteria, 110 knee osteoarthritis patients were randomly divided into 2 groups: steam-wash group and control group, 55 cases in each group. Based on the sign and symptom measure scale, the scores were calculated before treatment. And then the patients were treated by Haitongpi decoction steam-wash therapy or Votalin Emulgel. At 1 month after treatment, the changes of clinical symptom, physical sign, pain score, and the differences in side effect, lose and recurrence rate in the 2 groups were compared.

RESULT AND CONCLUSION: Both treatments were effective in reducing sign and symptom of knee osteoarthritis. The steam-wash group (controlled and remarkable effective rate was 57.45%, and total effective rate was 95.74%) was superior to the control group (controlled and remarkable effective rate was 36.96%, and total effective rate was 78.26%). The pain score was decreased after treatment in both groups (P < 0.01 or P < 0.05), especially showed superiority in the steam-wash group (P < 0.01). There cases in the steam-wash group and 2 cases in the control group suffered skin allergic reaction, the reaction was relieved after 1-2 days rest, and the difference had no difference. The recurrence rate of the steam-wash group was lower than that of the control group. All results demonstrated that steam-wash therapy with Haitongpi decoction is effective for early stage and moderate knee osteoarthritis. Compared with Votalin Emulgel, Haitongpi decoction steam-wash therapy exhibits superior outcomes and low recurrence rate. 

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