中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (8): 1471-1474.doi: 10.3969/j.issn.1673-8225.2010.08.034

• 生物材料临床实践 clinical practice of biomaterials • 上一篇    下一篇

缓释型氟尿嘧啶植入剂应用于乳腺癌改良根治的安全性

朱德淼   

  1. 辽宁医学院附属第一医院乳腺外科，辽宁省锦州市  121001
  • 出版日期:2010-02-19 发布日期:2010-02-19
  • 作者简介:朱德淼★，男，1976年生，辽宁省大连市人，汉族， 2007年辽宁医学院附属第一医院毕业，硕士，医师，主要从事乳腺外科常见病多发病的诊治。 lele8108@163.com

Safety of fluorouracil implants for modified radical mastectomy

Zhu De-miao   

  1. Department of Galactophore Surgery, First Hospital Affiliated to Liaoning Medical University, Jinzhou   121001, Liaoning Province, China
  • Online:2010-02-19 Published:2010-02-19
  • About author:Zhu De-miao★, Master, Physician, Department of Galactophore Surgery, First Hospital Affiliated to Liaoning Medical University, Jinzhou 121001, Liaoning Province, China lele8108@163.com

PDF

764

被引次数

26

摘要：

背景：如何寻找更好的药物剂型、给药途径，使高浓度的药物直接作用于局部，并提高药物对局部靶组织的选择性、延长药物作用时间，对预防乳腺癌局部复发有重要意义。
目的：探索在乳腺癌改良根治术中应用氟尿嘧啶植入剂的临床安全性，探寻预防乳腺癌局部复发的新途径。
方法：63例乳腺癌改良根治术患者，TNM分期：Ⅰ+Ⅱ期35例，Ⅲ期28例，随机分为植入剂组32例及对照组31例，植入剂组在肿瘤下方，腋窝、锁骨下血管区域、胸大小肌之间多点喷撒氟尿嘧啶植入剂，总剂量为600 mg，每点处小于100 mg，观察应用植入剂后，切口有无感染裂开，8 d后的皮下积液情况，皮瓣坏死、患肢水肿、拆线天数及血红、白细胞、肝肾功能情况。
结果与结论：植入剂组与对照组在切口感染裂开、皮下积液量、患肢水肿、拆线天数及血红细胞计数等方面差异无显著性意义(P > 0.05)，两组治疗后，血白细胞计数、谷丙转氨酶、肌酐均较治疗前有明显增加(P < 0.05)，但是两组之间差异无显著性意义(P > 0.05)。结果提示乳腺癌改良根治术中应用氟尿嘧啶植入剂是安全可靠的，是乳腺癌术后局部化疗的有效途径。

关键词: 乳腺癌, 改良根治术, 氟尿嘧啶植入剂, 安全性, 缓释材料, 药物控释系统及其载体材料

Abstract:

BACKGROUND: It is of significance for looking for ideal pharmaceutical dosage form and administration route to make sure direct action in local region, improve selection of high-concentration drug to local target tissue, prolong drug action, and prevent local recurrence of breast cancer.
OBJECTIVE: To explore the clinical safety of fluorouracil implants for modified radical mastectomy, and investigate the new way to prevent the local recurrence of breast cancer.
METHODS: A total of 63 cases with breast cancer treated by modified radical mastectomy in TNM stage of Ⅰ+Ⅱ (n=35) and Ⅲ(n=28) were randomly divided into control group (n=31) and implant group (n=32). Fluorouracil implants (600 mg in total, less than 100 mg at each site) were multiple-implanted below the tumor and in the armpits, subclavian vascular region, and axillary vascular area, so as to observe the incision infection or dehiscence, the subcutaneous fluid volume after 8 days, flap necrosis, limb edema, stitches days, WBC, RBC, hepatic and renal function.
RESULTS AND CONCLUSION: The differences in the incision infection or dehiscence, the subcutaneous fluid volume after 5 days, flap necrosis, limb edema, stitches days, and RBC between two groups were not significantly. Levels of WBC, glutamic-pyruvic transaminase, and creatinine were significantly increased after operation compared with before operation (P < 0.05), but there was no significant difference between the two groups (P > 0.05), suggesting that the method of implanting sustained-release fluorouracil for modified radical mastectomy was safe, and it might become an effective way to  local chemotherapy for breast cancer postoperatively.

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