中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (6): 1084-1087.doi: 10.3969/j.issn.1673-8225.2010.06.028

• 干细胞综述 • 上一篇    下一篇

造血干细胞自我更新的相关信号分子：作用及途径

李  娜，石增立，王跃嗣   

  1. 滨州医学院病理生理学专业，山东省烟台市 264003
  • 出版日期:2010-02-05 发布日期:2010-02-05
  • 作者简介:李 娜，女，1982年生，山东省滨州市人，汉族，滨州医学院病理生理学专业2007级在读硕士，主要从事造血干细胞发育、扩增调控方面的研究。 lina_200703@163.com

Signal molecules related to self-renewal of hemopoietic stem cells: Effects and pathways

Li Na, Shi Zeng-li, Wang Yue-si   

  1. Department of Pathophysiology, Binzhou Medical College, Yantai   264003, Shandong Province, China
  • Online:2010-02-05 Published:2010-02-05
  • About author:Li Na, Studying for master’s degree, Department of Pathophysiology, Binzhou Medical College, Yantai 264003, Shandong Province, China lina_200703@163.com

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摘要：

背景：造血干细胞数目少，且在体外容易分化，这对其应用于移植存在很大的困难。

目的：文章集中阐述了Wnt、Notch、Bmi_1、Shh、HOXB4信号分子在维持造血干细胞自我更新调控中的作用及其途径。

方法：以HSC、Wnt、Notch、Bmi_1、Shh、HOXB4为检索词，检索PubMed数据库(2002-01/2008-12)。文献检索语种限制为英文。纳入与造血干细胞自我更新相关信号分子密切相关的文献。排除重复性研究和Meta分析。

结果与结论：计算机初步检索到216篇文献，对其中30篇文献进行研究。造血干细胞是具有自我更新、较强分化发育和再生能力、可以产生各种类型血细胞的始祖细胞，被广泛应用于治疗血液系统疾病，但是造血干细胞在体外容易分化，这对其应用于移植存在很大的困难。如何使造血干细胞在体外扩增和处理的同时保持造血干细胞的自我更新特性成为关键问题。近年来通过不同信号通路增强造血干细胞自我更新能力的信号分子成为研究热点。文章集中阐述了Wnt、Notch、Bmi_1、Shh、HOXB4在维持造血干细胞自我更新调控中的作用及其途径，发现上述5种信号分子均具有增强造血干细胞自我更新的功能。此外还有一些因素在维持造血干细胞自我更新的过程中起重要作用，如作为内源性因素的一系列转录因子Oct-4、Ehox、Nanog、SCL、Runx1等，探讨它们相互作用形成的调控网络如何调控造血干细胞的自我更新，将成为造血干细胞自我更新领域研究的一个重点。

关键词: 信号分子, HSC, Wnt, Notch, Bmi_1, Shh, HOXB4, 造血干细胞

Abstract:

BACKGROUND: There are small amount of hematopoietic stem cells, which are easy to divide in vitro and show the difficulty in applying to transplantation.

OBJECTIVE: This paper has focused on the role and means of the Wnt, Notch, Bmi_1, Shh, HOXB4 signaling molecule in the maintenance of hematopoietic stem cell self-renewal and regulation.

METHODS: With the key words of “HSC, Wnt, Notch, Bmi_1, Shh, HOXB4” for the search, we searched PubMed database (2002-01/2008-12) in English. Literatures closely related to the hematopoietic stem cell self-renewal related signaling molecules were included. Repetitive research and Meta analysis were excluded.

RESULTS AND CONCLUSION: The computer initially retrieved 216 documents, of which 30 documents for research. Hematopoietic stem cells are self-renewing, have strong differentiation and growth and regeneration capacities, can produce various types of blood cells ancestor cells, are widely used to treat blood diseases, but the hematopoietic stem cell differentiation in vitro demonstrated that the difficulties used in transplantation. How to make hematopoietic stem cells in vitro amplification and processing, while maintaining hematopoietic stem cell self-renewal characteristics is of a key issue. In recent years, different signaling pathways to enhance the ability of hematopoietic stem cell self-renewal signaling molecule have been a research hotspot. The article focused on the role and means of the Wnt, Notch, Bmi_1, Shh, HOXB4 in the maintenance of hematopoietic stem cell self-renewal and regulation and found that both the above-mentioned five signaling molecules can enhance hematopoietic stem cell self-renewal function. There are also a number of factors playing an important role in the maintenance of hematopoietic stem cell self-renewal process, such as endogenous factors, a series of transcription factors Oct-4, Ehox, Nanog, SCL, Runx1 and so on, to explore how their regulatory networks formed by the interaction control self-renewal of hematopoietic stem cells will become a key point in the research of self-renewal of hematopoietic stem cells.

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