中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (2): 360-364.doi: 10.3969/j.issn.1673-8225.2010.02.040

• 组织构建临床实践 clinical practice in tissue construction • 上一篇    下一篇

绝经妇女体成分与代谢综合征组分的相关性

金  婧1，阮祥燕1，华  琳2   

  1. 1首都医科大学附属北京妇产医院内分泌科，北京市   100026；2首都医科大学生物信息学教研室，北京市   100069
  • 出版日期:2010-01-08 发布日期:2010-01-08
  • 通讯作者: 阮祥燕，博士，主任医师，首都医科大学附属北京妇产医院内分泌科，北京 市 100026 ruanxiangyan@163.com
  • 作者简介:金 婧★，女，1981年生，重庆市奉节县人，汉族，2008年首都医科大学毕业，硕士，医师，主要从事妇科内分泌绝经相关研究。 ireneking1981@hotmail.com
  • 基金资助:

    北京市自然科学基金资助项目(3082011)；首都医学发展基金重点支持项目 (2007-2045)。

Correlation between body composition and the components of metabolic syndrome in postmenopausal women 

Jin Jing1, Ruan Xiang-yan1, Hua Lin2   

  1. 1 Department of Endocrine, Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University, Beijing   100026, China; 2 Department of Bioinformatics, Capital Medical University, Beijing   100069, China
  • Online:2010-01-08 Published:2010-01-08
  • Contact: Ruan Xiang-yan, Doctor, Chief physician, Department of Endocrine, Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University, Beijing 100026, China ruanxiangyan@163.com
  • About author:Jin Jing★, Master, Physician, Department of Endocrine, Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University, Beijing 100026, China ireneking1981@hotmail.com
  • Supported by:

    the Natural Science Foundation of Beijing, No. 3082011*; Key Program of Medical Capital Development Fund, No. 2007-2045*

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421

被引次数

18

摘要：

目的：了解绝经妇女代谢综合征各组分异常的发生现状，以期得到预测绝经妇女代谢综合征各组分异常的体成分敏感指标。
方法：选取2006-07/2007-08在北京妇产医院体检并被确诊为自然绝经的妇女181名。年龄41~60岁，绝经年限1~9年。测量181名绝经妇女身高、体质量、腰围、臀围、血压及腹部矢状径，测定其卵泡刺激素、黄体生成素、雌二醇、三酰甘油、高密度脂蛋白胆固醇、空腹血糖及体脂含量。观察绝经妇女代谢综合征各组分异常的发生情况。消除年龄、绝经年限及雌二醇水平的影响，对绝经妇女体成分指标与代谢综合征各组分进行偏相关分析。预测绝经妇女代谢综合征各组分发生异常的体成分敏感指标的选取。
结果： ①绝经妇女中心型肥胖(腰围≥80 cm)、高三酰甘油(三酰甘油≥1.7 mmol/L)、低高密度脂蛋白胆固醇(高密度脂蛋白胆固醇< 1.29 mmol/L)、高血压(收缩压≥130 mm Hg(1 mm Hg=0.133 kPa)或 舒张压≥85 mm Hg)、高血糖(空腹血糖≥  5.6 mmol/L)的患病率分别为48.1%，31.5%，16.6%，38.7%，50.3%。②消除年龄、绝经年限及雌二醇水平的影响，体成分指标(体质指数、腰围、腰臀比、腹部矢状径、体脂含量)与三酰甘油、收缩压、舒张压、空腹血糖呈正相关，与高密度脂蛋白胆固醇呈负相关。③预测绝经妇女代谢综合征各组分发生异常的敏感指标及其临界值分别为：高三酰甘油：体质指数≥24.845 kg/m2；低高密度脂蛋白胆固醇：腹部矢状径≥18.85 cm；高血压：体质指数≥23.33 kg/m2；高血糖：腹部矢状径≥18.10 cm或体脂含量≥36.515%。
结论：中心型肥胖及高血糖是绝经妇女最常见的代谢紊乱。肥胖是绝经妇女代谢综合征各组分发生异常的独立危险因素。初步发现预测绝经妇女代谢综合征各组分发生异常的体成分敏感指标及其临界值。

关键词: 绝经, 代谢综合征, 体成分

Abstract:

OBJECTIVE: To learn the prevalence of abnormal components of metabolic syndrome in postmenopausal women, and to explore the optimal body composition indices to predict the abnormal components of metabolic syndrome in postmenopausal women.
METHODS: A total of 181 participants were recruited from postmenopausal women who came to Beijing Obstetrics and Gynecology Hospital for health examination between July 2006 and August 2007. They were 41-60 years of age, and there were 1-9 years since menopause. Their clinical and biochemical parameters were measured, including body height, body weight, waist circumference, hip circumference, sagittal abdominal diameter, blood pressure, follicle stimulating hormone, luteinizing hormone, estradiol, triglyceride, high density lipoprotein-cholesterol, fasting plasma glucose, fasting insulin and body fat. The prevalence of the abnormal components of metabolic syndrome in postmenopausal women was investigated. The correlations between body composition indices and the components of metabolic syndrome were analyzed by partial correlation analysis independent of age, years since postmenopause and the level of estradiol. The body composition indices to predict the abnormal components of metabolic syndrome in postmenopausal women were explored.
RESULTS: ①The prevalence of central obesity (waist circumference ≥ 80 cm), hypertriglyceridemia (triglyceride ≥   
1.7 mmol/L), low high density lipoprotein-cholesterol (high density lipoprotein-cholesterol < 1.29 mmol/L), hypertension (systolic pressure ≥ 130 mm Hg or diastolic pressure ≥ 85 mm Hg, 1 mm Hg=0.133 kPa) and high fasting glucose (fasting plasma glucose ≥ 5.6 mmol/L) was 48.1%, 31.5%, 16.6%, 38.7% and 50.3%, respectively. ②Through partial correlation analysis, body composition indices (body mass index, waist circumference, waist-hip ratio, sagittal abdominal diameter, and body fat) had a positive correlation with triglyceride, systolic pressure, diastolic pressure and fasting plasma glucose, while a negative correlation with high density lipoprotein-cholesterol, independent of age, years since postmenopause and the level of estradiol. ③Body composition indices and critical value of them used to predict the abnormal components of metabolic syndrome in postmenopausal women were as follows: hypertriglyceridemia: body mass index ≥ 24.845 kg/m2; low high density lipoprotein-cholesterol: sagittal abdominal diameter ≥ 18.85 cm; hypertension: body mass index ≥ 23.33 kg/m2; high fasting glucose: sagittal abdominal diameter ≥ 18.10 cm or body fat ≥ 36.515%.
CONCLUSION: Central obesity and high fasting glucose are the most common metabolic disorders in postmenopausal women. Obesity is an independent risk factor of metabolic syndrome for postmenopausal women. Body composition indices and their critical values to predict the abnormal components of metabolic syndrome in postmenopausal women are found.

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