中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (1): 179-182.doi: 10.3969/j.issn.1673-8225.2010.01.038

• 干细胞综述 • 上一篇    下一篇

再生障碍性贫血患者骨髓间充质干细胞体外生物学特性与其免疫调节缺陷

何  丽，肖  扬   

  1. 解放军广州军区总医院血液科，广东省广州市  510010
  • 出版日期:2010-01-04 发布日期:2010-01-04
  • 作者简介:何 丽，女，1986年生，江西省新余市人，汉族，广州中医药大学在读硕士，主要从事骨髓间充质干细胞对再生障碍性贫血的免疫调节及造血作用的研究。 heli19860502@qq.com

In vitro biological characteristics and immune regulation defects of bone marrow-derived mesenchymal stem cells from patients with aplastic anemia

He Li, Xiao Yang   

  1. Department of Hematology, General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou   510010, Guangdong Province, China
  • Online:2010-01-04 Published:2010-01-04
  • About author:He Li, Studying for master’s degree, Department of Hematology, General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou 510010, Guangdong Province, China heli19860502@qq.com

PDF

522

被引次数

21

摘要：

背景：许多报道指出骨髓间充质干细胞具有免疫调节及造血功能作用，而再生障碍性贫血患者骨髓间充质干细胞与正常人骨髓间充质干细胞在免疫调节及造血功能都存在显著差异。

目的：对再生障碍性贫血患者骨髓间充质干细胞的体外生物学特点及与免疫调节缺陷之间的关系进行综述。

方法：由第一作检索Pubmed数据库(1987/2009)和维普数据库(1989/2009)，英文检索词为“Mesenchymal stem cell，Bone marrow”；中文检索词为“再生障碍性贫血，间充质干细胞”，总计检索到文献55篇。纳入与再生障碍性贫血患者骨髓间充质干细胞生物学特性相关及与再生障碍性贫血患者免疫调节相关的文献。排除重复性研究及与主题非密切相关的文献。符合纳入标准的32篇文献中，英文综述3篇，英文研究论文23篇，中文研究论文6篇。

结果与结论：骨髓间充质干细胞具有高度增殖、自我更新及多向分化的能力，除支持造血、促进植入及体内造血重建等作用之外，还具有免疫负调节及降低移植物抗宿主病发生率的作用。再生障碍性贫血发病机制与造血干细胞内在增殖或分化缺陷，造血微环境系统异常以及机体免疫功能紊乱等有关，而再生障碍性贫血患者骨髓间充质干细胞的异常可能在其发病机制中存在重要作用。

关键词: 再生障碍性贫血, 骨髓, 间充质干细胞, 免疫调节, T淋巴细胞, 综述文献

Abstract:

BACKGROUND: Previous research has indicated that bone marrow-derived mesenchymal stem cells had immunological regulation and hematopoiesis role. There were significant differences in immunological regulation and hemopoietic function between patients with aplastic anemia and normal cases.

OBJECTIVE: To summarize the in vitro biological characteristics and its immune regulation defects of bone marrow-derived mesenchymal stem cells from patients with aplastic anemia.

METHODS: A computer-based online search was conducted in PUMMED (1987-2009) and VIP database (1989-2009) with the key words of “mesenchymal stem cell, bone marrow” in both Chinese and English. There were 55 articles in total. Articles which were related to biological characteristics and its immune regulation defects of bone marrow-derived mesenchymal stem cells were included; however, duplicated articles were excluded. Finally, 32 articles were included, containing 3 reviews in English, 23 original articles in English, and 6 original articles in Chinese.

RESULTS AND CONCLUSION: Bone marrow-derived mesenchymal stem cells had the capacities of high proliferation, self-renewal and multilineage differentiation; in addition they had the roles of supporting hematopoiesis, promoting implantation and hematopoietic reconstitution in vivo. Bone marrow-derived mesenchymal stem cells still had the effects of negative immune regulation and reducing the incidence of graft-versus-host disease (GVHD). Aplastic anemia correlated with hematopoietic stem cells in the pathogenesis of intrinsic defects in the proliferation or differentiation of hematopoietic microenvironment and immune system abnormalities and other related disorders. Bone marrow-derived mesenchymal stem cells of patients with aplastic anemia played an important role in the pathogenesis of this disease.

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