中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (1): 161-165.doi: 10.3969/j.issn.1673-8225.2010.01.034

• 干细胞综述 • 上一篇    下一篇

干细胞治疗感音神经性聋的研究理论及其临床应用进展

秦  贺，杨仕明，翟所强   

  1. 解放军总医院耳鼻咽喉头颈外科，解放军耳鼻咽喉研究所耳神经生物中心，北京市 100853
  • 出版日期:2010-01-04 发布日期:2010-01-04
  • 通讯作者: 杨仕明，博士，主任医师，教授，解放军总医院耳鼻咽喉头颈外科，解放军耳鼻咽喉研究所耳神经生物中心，北京市 100853 yangsm301@263.net
  • 作者简介:秦 贺，男，1977年生，山东省郓城县人，汉族，解放军军医进修学院2007级在读博士，主治医师，主要从事耳科学基础与临床方面的研究。 heqin007@126.com
  • 基金资助:

    国家863计划(2007AA02Z150)；
    国家“十一五”科技支撑计划(2006BAI02B06)；
    国家自然科学基金重点项目(30730040)；
    国家自然科学基金面上项目(30571017；30871398)；
    海外青年学者合作研究基金(30628030)。

Application and research progress in stem cells therapy for sensorineural deafness

Qin He, Yang Shi-ming, Zhai Suo-qiang   

  1. Department of Otolaryngology Head and Neck Surgery, PLA General Hospital, Oto-Neurological Biologic Center, PLA Institute of Otolaryngology, Beijing   100853, China
  • Online:2010-01-04 Published:2010-01-04
  • Contact: Zhai Suo-qiang, Doctor, Investigator, Professor, Department of Otolaryngology Head and Neck Surgery, PLA General Hospital, Oto-Neurological Biologic Center, PLA Institute of Otolaryngology, Beijing 100853, China zhaisq@plagh.com.cn
  • About author:Qin He, Studying for doctorate, Attending physician, Department of Otolaryngology Head and Neck Surgery, PLA General Hospital, Oto-Neurological Biologic Center, PLA Institute of Otolaryngology, Beijing 100853, China heqin007@126.com
  • Supported by:

    the National High-Tech Research and Development Program of China (“863” Program) , No. 2007AA02Z150*;
    the Science and Technology Supporting Program during the Eleventh-Five-Year Plan Period, No. 2006BAI02B06*;
    the Key Program of National Natural Science Foundation of China, No. 30730040*;
    the General Program of National Natural Science Foundation of China, No. 30571017*, 30871398*;
    the Overseas Young Scholar Cooperation Research Foundation, No. 30628030

PDF

560

被引次数

19

摘要：

背景：内耳毛细胞或螺旋神经元的丢失可引起感音神经性聋。内耳细胞死亡后，利用干细胞研究来恢复听力已成为近年来研究热点。

目的：总结近年来干细胞向内耳细胞方向分化的体内外研究进展，对干细胞进行感音神经性聋后内耳细胞替代治疗的研究成果进行综述。

方法：应用计算机检索Pubmed数据库(2000-01/2009-08)，检索词为“inner ear，Stem cells”；应用计算机检索CNKI数据库(2000-01/2009-08)，检索词为“内耳、干细胞”。

结果与结论：计算机初检得到170篇文献，纳入与干细胞在感音神经性聋的细胞转化有密切关系的实验研究和综述，排除重复研究类文献，对符合条件的32篇文献进行汇总分析。不同类型干细胞具有向内耳细胞分化的能力，能够分化为神经源性细胞类型。干细胞移植到内耳结构中可以发生迁移、分化，并部分分化为损伤区域的细胞类型，为感音神经性聋听力恢复提供了一条治疗途径。如何使分化细胞发挥正常生理功能，移植到内耳后能否建立神经通路，是干细胞治疗感音神经性聋下一步研究方向。

关键词: 干细胞, 听觉丧失, 感音神经性, 细胞分化, 移植

Abstract:

BACKGROUND: The sensorineural deafness occurs as a result of loss of inner ear hair cells in the cochlea or of their primary afferent the spiral ganglion neurons. Stem cells to restore hearing following inner ear cell death has become a focus in recent years.

OBJECTIVE: To summarize research progress in stem cells differentiating into inner ear cells in vitro and in vivo and to review the achievement in stem cells replacing inner ear cells in treating sensorineural deafness.

METHODS: With “inner ear, stem cells” as key words, a computer-based online search of Pubmed and CNKI was performed for articles published from January 2000 to August 2009.

RESULTS AND CONCLUSION: A total of 170 articles were collected, and experimental studies and review articles on stem cells in sensorineural deafness were included, while repetitive articles were excluded. Finally, 32 articles were summarized and analyzed. Different types of stem cells have the capacity to differentiate into inner ear cells. They can differentiate into neural cell types. Stem cells can live and migrate, differentiating into cell types of the sites of injury. It provides a therapy strategy to restore hearing following sensorineural deafness by he capacity of stem cells differentiating into inner ear cells. However, it remains further investigation how to function following cell differentiation and how to form the appropriate neural pathways by stem cell transplantation in sensorineural deafness.

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