中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (10): 2584-2593.doi: 10.12307/2026.625

• 组织构建循证医学 evidence-based medicine in tissue construction • 上一篇    下一篇

高强度间歇训练与中等强度持续训练对冠心病患者影响的Meta分析

胡玉洁1，谢  萍1，2，卢维杰3，杨  康3，邓耀庭3，刘梦洋3   

  1. 1兰州大学第一临床医学院，甘肃省兰州市  730000；2甘肃省人民医院，甘肃省兰州市  730000；3甘肃中医药大学，甘肃省兰州市  730000
  • 收稿日期:2025-04-03 接受日期:2025-06-08 出版日期:2026-04-08 发布日期:2025-08-30
  • 通讯作者: 谢萍，博士，主任医师，教授，博士生导师，兰州大学第一临床医学院，甘肃省兰州市 730000；甘肃省人民医院，甘肃省兰州市 730000
  • 作者简介:胡玉洁，女，1999年生，陕西省渭南市人，汉族，兰州大学第一临床医学院在读硕士，主要从事心血管疾病方向的研究。
  • 基金资助:
    甘肃中医药大学创新创业项目(2025CXZX-917)，项目负责人：卢维杰

Meta-analysis of the clinical efficacy of high-intensity interval exercise and middle-intensity continuous training in patients with coronary heart disease

Hu Yujie1, Xie Ping1, 2, Lu Weijie3, Yang Kang3, Deng Yaoting3, Liu Mengyang3   

  1. 1The First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, China; 2Guansu Provincial People’s Hospital, Lanzhou 730000, Gansu Province, China; 3Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • Received:2025-04-03 Accepted:2025-06-08 Online:2026-04-08 Published:2025-08-30
  • Contact: Xie Ping, PhD, Chief physician, Professor, Doctoral supervisor, The First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, China; Guansu Provincial People’s Hospital, Lanzhou 730000, Gansu Province, China
  • About author:Hu Yujie, MS candidate, The First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, China
  • Supported by:
    Gansu University of Chinese Medicine Innovation and Entrepreneurship Program, No. 2025CXZX-917 (to LWJ)

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摘要：


文题释义：
中等强度持续训练：是一种以中等强度进行持续性有氧运动的训练方式，整个训练过程中强度恒定，常持续30 min左右，通过稳定的运动强度和较长持续时间来提升心肺耐力、改善代谢功能、促进整体健康。中等强度持续训练适合大多数人群，尤其是初学者、老年人、慢性疾病患者以及希望长期坚持运动以改善健康的人群。
高强度间歇训练：是一种重复进行高强度训练且在训练之间设置短暂休息的训练方法，特点是短时间内进行极高强度的运动，随后进行较低强度的恢复或完全休息，如此循环往复。

目的：研究表明，高强度间歇训练在改善冠心病患者心肺功能方面可能优于中等强度持续训练，但高强度间歇训练的临床疗效仍存在争议。此次研究旨在系统评估高强度间歇训练与中等强度持续训练对冠心病患者临床疗效的影响。
方法：通过检索中国知网、万方数据库、维普数据库、PubMed、Cochrane Library、Embase、Web of Science等数据库，选择高强度间歇训练、中等强度持续训练应用于冠心病心脏康复有关的随机对照试验，使用Review Manager 5.3及StataMP 17软件对最终纳入的文献进行Meta分析。
结果：共纳入10篇文献，包括786例患者。Meta分析结果显示，高强度间歇训练组峰值摄氧量、第一通气阈时摄氧量均高于中等强度持续训练组[MD=1.30，95%CI(0.71，1.89)，P < 0.000 1；MD=1.54，95%CI(0.56，2.53)，P=0.002]，两组间静息心率、峰值心率、静息收缩压与静息舒张压比较差异均无显著性意义(P > 0.05)。
结论：相较于中等强度持续训练，高强度间歇训练在改善冠心病患者峰值摄氧量及第一通气阈时摄氧量方面更有优势，而对静息心率、峰值心率、静息收缩压、静息舒张压无明显影响。
https://orcid.org/0009-0002-1787-4284(胡玉洁)

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 冠心病, 高强度间歇训练, 中等强度持续训练, 心脏康复, 临床疗效, 随机对照研究, Meta分析

Abstract: OBJECTIVE: Although existing studies have suggested that high-intensity interval training may be more effective than moderate-intensity continuous training in improving cardiopulmonary function in patients with coronary heart disease, its clinical efficacy remains controversial. Therefore, this meta-analysis aims to systematically evaluate the clinical efficacy of high-intensity interval training versus moderate-intensity continuous training in patients with coronary heart disease. 
METHODS: Randomized controlled trials of high-intensity interval training and moderate-intensity continuous training in cardiac rehabilitation of coronary heart disease were included by searching Chinese and English databases such as CNKI, WanFang Database, Wipro, PubMed, Cochrane Library, Embase, and Web of science. Meta-analysis of the final included literature was performed using Review Manager 5.3 and StataMP 17. 
RESULTS: A total of 10 studies met the study criteria and included 773 patients. Compared with moderate-intensity continuous training, high-intensity interval training resulted in higher peak oxygen uptake and oxygen uptake at the first ventilatory threshold were higher [mean difference=1.30, 95% confidence interval (0.71, 1.89), P < 0.000 1; mean difference=1.54, 95% confidence interval (0.56, 2.53), P=0.002]. Both groups showed no significant difference in resting systolic blood pressure, resting diastolic blood pressure, resting heart rate and peak heart rate (P > 0.05). 
CONCLUSION: Compared with moderate-intensity continuous training, high-intensity interval training is more advantageous in improving peak oxygen uptake and oxygen uptake at the first ventilation threshold in coronary artery disease, while has no significant effects on resting heart rate, peak heart rate, resting systolic blood pressure, and resting diastolic blood pressure.


Key words: coronary heart disease, high-intensity interval exercise, moderate-intensity aerobic exercise, cardiac rehabilitation, clinical efficacy, randomized controlled trial, meta-analysis

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