中国组织工程研究 ›› 2024, Vol. 28 ›› Issue (8): 1206-1210.doi: 10.12307/2023.961

• 组织构建与生物力学 tissue construction and biomechanics • 上一篇    下一篇

血管数量对小血管网计算流体力学的影响

代越星1,2,郑利钦1,吴敏辉1,李志鸿1,李少彬1,郑德声1,林梓凌3   

  1. 1广州中医药大学第一临床医学院,广东省广州市  510405;2广州中医药大学岭南医学研究中心数字骨科与生物力学实验室,广东省广州市 510405;3广州中医药大学第一附属医院创伤骨科,广东省广州市  510405
  • 收稿日期:2022-11-18 接受日期:2023-01-04 出版日期:2024-03-18 发布日期:2023-07-18
  • 通讯作者: 林梓凌,博士,主任医师,教授,博士生导师,广州中医药大学第一附属医院创伤骨科,广东省广州市 510405
  • 作者简介:代越星,女,1997年生,重庆市人,汉族,医师,主要从事骨与关节生物力学的研究。
  • 基金资助:
    国家自然科学基金(81673996),项目负责人:林梓凌

Effect of vessel number on computational fluid dynamics in vascular networks

Dai Yuexing1, 2, Zheng Liqin1, Wu Minhui1, Li Zhihong1, Li Shaobin1, Zheng Desheng1, Lin Ziling3   

  1. 1The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; 2Laboratory of Digital Orthopedics and Biomechanics, Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; 3Department of Orthopedic Trauma, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
  • Received:2022-11-18 Accepted:2023-01-04 Online:2024-03-18 Published:2023-07-18
  • Contact: Lin Ziling, MD, Chief physician, Professor, Doctoral supervisor, Department of Orthopedic Trauma, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
  • About author:Dai Yuexing, Physician, The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; Laboratory of Digital Orthopedics and Biomechanics, Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
  • Supported by:
    National Natural Science Foundation of China, No. 81673996 (to LZL)

摘要:


文题释义:

计算流体力学:将流体力学控制方程中积分、微分项近似地表示为离散的代数形式,使其成为方程组,再通过计算机和数值方法求解流体力学的控制方程,获得离散的时间/空间点上的数值解,对流体力学问题进行模拟和分析,通过计算流体力学可以无创性地获得血流动力学指标,广义上从属于有限元法。
成血管-成骨偶联:在骨骼系统的生长发育及修复重建过程中,血管与骨联系密切且相互作用,骨血管系统起着为骨骼提供氧气、营养物质、生长因子及代谢废物等作用,而成骨细胞、骨细胞等对血管生成具有调节作用,血管生成与骨形成在时间和空间上的密切关系称成血管-成骨偶联。


背景:力学因素会影响血管内皮细胞的成血管能力,血管数量变化如何影响微血管流体力学性能还有待阐明。

目的:基于计算流体力探讨血管数量对小血管网流体力学的影响。
方法:利用ANSYS 19.0软件Geometry模块构建3种不同血管数量的小血管网三维模型,在Mesh模块进行网格划分,属性设定小血管网管壁为无滑移的刚性壁,血液为层流、黏性、不可压缩的牛顿流体,设定血液密度、入口血液流速等物理信息,采用Navier-Stokes(NS)方程组进行计算。分析比较在不同血管数量的情况下,小血管网不同部位流体力学性能差异。

结果与结论:血液流线、血液流速及质量流量在小血管网内均呈现出、入口处大,血管网中间交接处小;血管数量越多,小血管网各部位血液流线越稀疏,血液流速、质量流量、管壁剪切力随血管数量增加均呈下降趋势。血管数量会改变小血管网内流体力学环境。计算流体力学可以反映出小血管数量变化对血液流体力学性能的影响,为基于成血管-成骨偶联的补肾活血法治疗骨内灌注不足引起的相关骨骼疾病(骨折不愈合、骨缺损、骨质疏松症等)提供新的思路。

https://orcid.org/0000-0002-0740-7378(代越星)

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程

关键词: 血管数量, 计算流体力学, 成血管-成骨偶联, 补肾活血法, 骨折不愈合, 骨缺损, 骨质疏松症

Abstract: BACKGROUND: Mechanical factors can affect the angiogenic ability of vascular endothelial cells. How the vessel number affects the hydrodynamic properties of microvessels remains to be clarified. 
OBJECTIVE: To investigate the influence of vessel number on the hydrodynamics of vascular networks based on computational fluid dynamics. 
METHODS: Three three-dimensional models of vascular network with different vessel numbers were constructed using the Geometry module of ANSYS 19.0 software, and then the vascular network was meshed to tetrahedral elements in Mesh module. The vascular network was assumed to rigid wall without slip, and the blood was assumed to laminar, viscous, and incompressible Newtonian fluid. Blood density, velocity, and a series of blood viscosity coefficients were also established. The Navier-Stokes equation was used for calculation. Hydrodynamic properties of different parts of vascular network with different vessel numbers were analyzed and compared. 
RESULTS AND CONCLUSION: The streamline, velocity, and mass flow all had the same trend in the vascular network, that is, the outlet and inlet were higher and the middle junction of vascular network was lower. The more the number of vessels, the thinner the blood flow lines in each part of the vascular network. Also, the velocity, mass flow, and wall shear decreased with the increase of the number of blood vessels. Therefore, the changes in vessel number could influence the hydrodynamic environment in the vascular network. Computational fluid dynamics indicates that the changes in vessel numbers can influence the hydrodynamic properties of blood, and provides a new idea for treating bone hypoperfusion-induced diseases (fracture nonunion, bone defect, osteoporosis, etc.) through tonifying kidney and activating blood circulation based on the coupling between angiogenesis and osteogenesis.

Key words: vessel number, computational fluid dynamics, angiogenic-osteogenic coupling, tonifying kidney and activating blood circulation, fracture nonunion, bone defect, osteoporosis

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