Constructing a controlled-release dexamethasone-loaded titania nanotube system

doi:10.3969/j.issn.2095-4344.2014.16.014

Abstract

Abstract:

BACKGROUND: Compared with smooth titanium, titania nanotubes cannot only induce mesenchymal stem cells osteogenic differentiation and promote bone integration, but also be used as drug nanocarriers.

OBJECTIVE: To prepare dexamethasone-loaded titania nanotube system and to test its drug release characteristics.

METHODS: Titania nanotubes were prepared by electrochemical anodic oxidation, and dexamethasone was dripped onto the prepared titania nanotubes. Subsequently layer by layer self-assembly technology was employed to fabricate gelatin/chitosan multilayered structure on the prepared samples. Scanning electron microscope and contact angle test were carried out during the process of building the gelatin/chitosan multilayered structure. The drug release was measured by a ultraviolet spectrophotometer.

RESULTS AND CONCLUSION: Under the scanning electron microscopy, the fabricated titania nanotubes had integral structure with even tube size of about 70 nm and arranged regularly, and the nanotubes were completely covered and sealed by the gelatin/chitosan multilayered membrane. Contact angle test results showed that ever since the fifth layer, contact angles changed alternately and displayed a zigzag profile. Ultraviolet spectrophotometer test results showed that when cultured for 3 hours, the cumulative drug release was about 32.7% and demonstrated an initial burst followed by sustained release. When cultured for 24 hours, the cumulative drug release about 52.3%. However, after cultured for 7 days, little drug release was detected. And there was about 8.0%-10.0% dexamethasone of initial loading preserved in nanotubes.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: biocompatiblematerials, nanotubes, dexamethasone

CLC Number:

R318

Wang Ming, Zhang He, Wang Lu, Deng Feng, Yang Sheng . Constructing a controlled-release dexamethasone-loaded titania nanotube system[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(16): 2544-2549.

Figures/Tables 2

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