Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (7): 1081-1087.doi: 10.3969/j.issn.2095-4344.2176

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Strategies for improving the therapeutic efficacy of mesenchymal stem cells in the treatment of nonhealing wounds

Wang Xianyao1, 2, Guan Yalin3, Liu Zhongshan3   

  1. 1Center for Tissue Engineering and Stem Cell Research, Guizhou Medical University, Guiyang 550004, Guizhou Province, China; 2Department of Immunology, Guizhou Medical University, Gui'an New Area 550025, Guizhou Province, China; 3Department of Burn and Plastic Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou Province, China
  • Received:2020-04-18 Revised:2020-04-22 Accepted:2020-05-19 Online:2021-03-08 Published:2020-12-09
  • Contact: Liu Zhongshan, MD, Associate chief physician, Master’s supervisor, Department of Burn and Plastic Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou Province, China
  • About author:Wang Xianyao, Doctoral candidate, Center for Tissue Engineering and Stem Cell Research, Guizhou Medical University, Guiyang 550004, Guizhou Province, China; Department of Immunology, Guizhou Medical University, Gui’an New Area 550025, Guizhou Province, China
  • Supported by:
    the Science and Technology Cooperation Project of Guizhou Province, No. Qian Kehe LH word [2016] 7233

Abstract: BACKGROUND: Mesenchymal stem cell-based therapy is pursued aggressively with promising preclinical studies and higher future prospect in the treatment of nonhealing wounds.
OBJECTIVE: To review the strategies for improving the efficacy of mesenchymal stem cells in the treatment of nonhealing wounds, which are expected to provide theoretical basis for clinical treatment of nonhealing wounds.
METHODS: Wanfang, CNKI, PubMed and Web of Science were searched for articles about the application of mesenchymal stem cells in nonhealing wounds from March 2002 to March 2020. The key words were “mesenchymal stem cells, nonhealing wounds (nonhealing chronic wounds), wound repair, tissue regeneration” in Chinese and “mesenchymal stem cells, nonhealing chronic wound, wound repair, tissue regeneration” in English. After excluding outdated and repetitive viewpoints, the retrieved literature was sorted out and a total of 64 articles were included for analysis. 
RESULTS AND CONCLUSION: (1) The formation mechanism of nonhealing wounds was summarized. (2) The molecular mechanisms of mesenchymal stem cells in the treatment of nonhealing wounds were summarized, such as direct differentiation, paracrine, immunomodulatory, mobilization resident stem cells to participate in wound repair. (3) This paper summarized the improvement of the efficacy of mesenchymal stem cells in the treatment of nonhealing wounds, such as gene modification and pretreatment. (4) This study can provide a theoretical basis for improving the efficacy of mesenchymal stem cells in the treatment of nonhealing wounds. 

Key words: stem cells, mesenchymal stem cells, nonhealing wounds, genetic modifications, preconditioning, wound repair, review

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