Effects of long-acting antimicrobial material on pathogenic
distribution and serum inflammatory factor concentration in patients with
indwelling catheter

doi:10.3969/j.issn.2095-4344.2242

Abstract

Abstract:

BACKGROUND: Long-acting antimicrobial material is a new polymer activator of organosilicon quaternary ammonium salt and has obvious advantages in anti-infection.

OBJECTIVE: To investigate the effects of Jieyoushen, a long-acting antimicrobial material, on pathogenic distribution and serum inflammatory factors in patients with indwelling catheters.

METHODS: A total of 200 male patients with indwelling catheter who received treatment during January 2014 to January 2018 in Hainan West Central Hospital, China were included in this study. These patients were aged 35-55 years and were randomly divided into two groups: a control group (n=100) and an observation group (n=100). Patients in the control group were given routine urethral orifice nursing. Patients in the observation group were sprayed with long-acting antimicrobial material “Jieyoushen” on the urethral orifice, catheter and catheter bag interface. Infection was detected at 1, 3, 5 and 7 days after catheterization. The changes of pathogenic bacteria and serum inflammatory factors in two groups were analyzed at 7 days after catheterization. This study was approved by the Medical Ethics Committee, Hainan West Central Hospital, China (approval No. 2013120602).

RESULTS AND CONCLUSION: Compared with the control group, the infection rates of the patients in the observation group decreased significantly at 1, 3, 5 and 7 days after catheterization (P < 0.05). Twenty pathogenic bacteria were isolated in patients of the control group, including 13 Gram-positive bacteria (65.0%) and 7 Gram-negative bacteria (35.0%). Seven pathogenic bacteria were isolated in patients of the observation group, including 5 Gram-positive bacteria (71.4%) and 2 Gram-negative bacteria (28.6%). Compared with before indwelling catheter, serum levels of interleukin-1β, interleukin-2, homocysteine, and procalcitonin increased significantly in each group after catheterization (P < 0.05). After catheterization, serum levels of above-mentioned factors in the control group were significantly higher than those in the observation group (P < 0.05). These results suggest that long-acting antimicrobial material "Jieyoushen" can effectively reduce the infection rate of pathogenic bacteria and lower serum levels of inflammatory factors in patients with indwelling catheter.

Key words: long-acting antibacterial material, indwelling catheter, infection, pathogen, inflammatory factor, Gram-positive bacteria, Gram-negative bacteria, interleukin

CLC Number:

Liang Changwei, Pan Weixin, Cai Zhikang, Wang Zhong. Effects of long-acting antimicrobial material on pathogenic distribution and serum inflammatory factor concentration in patients with indwelling catheter[J]. Chinese Journal of Tissue Engineering Research, 2020, 24(10): 1580-1584.

Figures/Tables 6

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