Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (10): 1500-1506.doi: 10.3969/j.issn.2095-4344.3022
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Zhang Lixing1, Tian Ang2, Li Xi1, Bai Xizhuang1
Received:
2020-02-13
Revised:
2020-02-22
Accepted:
2020-05-09
Online:
2021-04-08
Published:
2020-12-17
Contact:
Bai Xizhuang, Professor, Department of Sports Medicine and Joint Surgery, People’s Hospital of China Medical University, Shenyang 110016, Liaoning Province, China
About author:
Zhang Lixing, Master candidate, Department of Sports Medicine and Joint Surgery, People’s Hospital of China Medical University, Shenyang 110016, Liaoning Province, China2020-02-13
Supported by:
CLC Number:
Zhang Lixing, Tian Ang, Li Xi, Bai Xizhuang. Drug-release characteristic and biological toxicity of TiO2 nanotube/hydroxyapatite loaded vancomycin coating[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(10): 1500-1506.
涂层累计释药量随时间变化结果:载药羟基磷灰石涂层在100 h内药物释放达到了总的载药量4 mg,载药二氧化钛纳米管涂层药物释放时间达到超过100 h,载药复合涂层药物释放时间超过了150 h,见图5。相比于载药二氧化钛纳米管涂层、载药羟基磷灰石涂层,载药复合涂层达到了更长的药物释放时间。涂层累计释药率随时间变化结果:载药羟基磷灰石涂层和载药二氧化钛纳米管涂层在前6 h的药物释放率超过了50%,载药复合涂层在12 h释药率达到50%,随后各组均有一个涂层缓释阶段,但载药复合涂层有比载药羟基磷灰石涂层和载药二氧化钛纳米管涂层更长的释药效能,见图6。各组前期药物快速释放之后药物会缓慢释放,其原因是吸附于涂层表面的药物会在几小时内快速释放,而装载在涂层及纳米管内部的药物则会随时间逐渐释放出来,表现出一定的药物缓释效能。 "
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