Broad-spectrum antibiotics prevent against early infection after hematopoietic stem cell transplantation

doi:10.3969/j.issn.2095-4344.2016.45.017

Abstract

Abstract:

BACKGROUND: Occurrence of acute graft-versus-host disease after hematopoietic stem cell transplantation is closely related to early infection, so controlling infection can decrease the transplant- related mortality.
OBJECTIVE: To explore effects of broad-spectrum antibiotics on the occurrence of early infection after hematopoietic stem cell transplantation.
METHODS: Clinical data of 31 patients undergoing autologous peripheral blood stem cell transplantation were collected. Within 30 days after cell transplantation, occurrence rate and types of early infection were detected and recorded. Besides, distribution of pathogens, as well as treatment and outcome of patients were statistically observed.
RESULTS AND CONCLUSION: All patients successfully underwent hematopoietic stem cell transplantation, and the occurrence rate of infection was 71% with no death at early stage after cell transplantation. Twenty strains of pathogens were detected, in which gram-negative bacteria accounted for 80%. In addition, there was a significant negative correlation between the number of neutrophils in the peripheral blood and the duration of infection (P < 0.01). These results indicate that the infection rate at early stage after hematopoietic stem cell transplantation is relatively higher, which is associated with reduction and recovery time of neutrophils. Therefore, it is advisable to choose appropriate broad-spectrum antibiotics for preventive treatment at early stage after cell transplantation, so as to quickly and effectively control infections.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Hematopoietic Stem Cells, Stem Cell Transplantation, Infection, Tissue Engineering

CLC Number:

R394.2

Duan Ling-xiao. Broad-spectrum antibiotics prevent against early infection after hematopoietic stem cell transplantation[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(45): 6801-6806.

Figures/Tables 1

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