Titanium dioxide nanotube composite coating: preparation and early drug-release

doi:10.3969/j.issn.2095-4344.2016.43.005

Abstract

Abstract:

BACKGROUND: The surface modification of pure titanium has become a hotspot for research on improving the early implant-osseointegration ability.
OBJECTIVE: To construct the icariin/TiO₂ nanotube composite coating, and to explore its drug-loading rate and early drug-release kinetics.
METHODS: Pure titanium was anodized to obtain TiO₂ nanotube. Thereafter, the pure titanium and TiO₂nanotube were characterized by scanning electron microscopy, atomic force microscopy and contact angle instrument. Icariin was loaded onto the pure titanium and TiO₂nanotube by immersion method. Afterwards, the early drug-releasing amount of the two materials was measured using high-performance liquid chromatography. Accumulated release and accumulated drug-release percentage curves were drawn.
RESULTS AND CONCLUSION: The diameter of TiO₂ nanotube was 80 nm, and the roughness of TiO₂nanotube was significantly higher than that of pure titanium (P < 0.05), but the contact angle was significantly lower than that of pure titanium (P < 0.05). Moreover, compared with the icariin/pure titanium group, the icariin/TiO₂ nanotube group had obviously higher accumulated drug-releasing amount at former 14 days and accumulated drug-releasing carve at former 4 hours. The accumulated drug-releasing percentage curve in the icariin/TiO₂ nanotube group was flatter than that in the icariin/pure titanium group, suggesting a longer release time. To conclude, the icariin/TiO₂ nanotube composite coating has a higher drug, loading and exerts better sustained-release effect.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Titanium, Nanotubes, Synostosis, Tissue Engineering

CLC Number:

R318

Wang Fei-fan, Song Yun-jia1, Wu Wen-meng, Lv Wu-long, Li Ying, Li Chang-yi.

Titanium dioxide nanotube composite coating: preparation and early drug-release

[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(43): 6416-6423.

Figures/Tables 4

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