Role of Sonic Hedgehog signal pathway in embryogenesis and neural regeneration

doi:10.3969/j.issn.2095-4344.2015.46.026

Abstract

Abstract:

BACKGROUND: Many studies have showed that Sonic Hedgehog (Shh) signal pathway regulates the proliferation and differentiation of nerve cells, axon guidance and neural regeneration after brain injury.
OBJECTIVE: To summarize the role of Shh signal pathway in embryonic development and post-natal nerve repair.
METHODS: A computer-based retrieval was performed by the first author in PubMed and CNKI database to search related papers published from January 1980 to July 2015 using the keywords of “Shh signal pathway, embryogenesis, neural regeneration” in English and Chinese, respectively. Articles related to Shh signal pathway in embryonic cells differentiation, tissue development, post-natal neural regeneration, axon migration and tumor formation. A total of 38 relevant literatures were retrieved.
RESULTS AND CONCLUSION: Recently, Shh signal pathway has become an issue of concern because this signal pathway is closely related with neural regeneration after brain injury. Shh is widely expressed in Hedgehog (Hh) family and plays a crucial role in embryogenesis and organogenesis. Shh is well known to contribute to the patterning of neural tube system, regulate the proliferation and migration of progenitor cells, and control axonal
growth and guidance. In addition, Shh is closely related to tumor formation. Studies have shown that Shh can reduce infarct volume and improve behavior prognosis of stroke rats.
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Embryonic Development, Nerve Regeneration, Cell Differentiation

Wang Su-ping, Wu Xiao-jun, Yan Xu, Zhao Hong. Role of Sonic Hedgehog signal pathway in embryogenesis and neural regeneration[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(46): 7523-7528.

Figures/Tables 1

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