Chinese Journal of Tissue Engineering Research ›› 2013, Vol. 17 ›› Issue (25): 4623-4628.doi: 10.3969/j.issn.2095-4344.2013.25.009

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Biocompatibility of gatifloxacin-poly(sebacic anhydride) local control release system  

Lu Feng, Zhang Hong-tu, Ma Shu-you   

  1. Department of Orthopedics, People’s Hospital of Zunhua City, Tangshan  064200, Hebei Province, China
  • Received:2012-10-29 Revised:2012-11-06 Online:2013-06-18 Published:2013-06-18
  • About author:Lu Feng★, Master, Attending physician, Department of Orthopedics, People’s Hospital of Zunhua City, Tangshan 064200, Hebei Province, China lhf4204@126.com

Abstract:

BACKGROUND: Polyanhydride material is characteristics of surface erosion, biodegradability and release rate adjustability, and it has been approved by the U.S. Food and Drug Administration for human drug carrier materials.
OBJECTIVE: To prepare gatifloxa-poly(sebacic anhydride) local control release system and study its biocompatibility.
METHODS: Poly(sebacic anhydride) was prepared with melt phase polycondensation method, and mixed with gatifloxacin in the agate mortar to make a local drug delivery system at 20% drug loading. Six rabbits were used to study the biocompatibility of poly(sebacic anhydride) and their back skin was cut open. Six rabbits were randomly divided into two groups, the experimental group was implanted with poly(sebacic anhydride) stick into the paraspinal muscle pouch, while the control group received no implants. Rabbits were killed at 5 weeks post-surgery, and changes on subcutaneous tissue and muscle tissue were observed, as well heart, liver, kidney, and lung. 
RESULTS AND CONCLUSION: Poly(sebacic anhydride) has a good biocompatibility. After implantation, no rabbit appeared to have the change of appetite and behavior. There was no edema, hemorrhage and erosion at the implanted site, and the surface of implanted materials was porous, which suggested that the materials had been degraded and absorbed subcutaneously. In addition, embrittlement and disintegration were not observed; the implanted materials slightly adhered to surrounding tissue. There was no change in the liver, kidney, lung, heart and partial musculature. Gatifloxacin-poly(sebacic anhydride) local sustained release preparation is well histocompatible with no toxicity and teratogenic action.

Key words: biomaterials, material biocompatibility, poly(sebacic anhydride), polyanhydride, gatifloxacin-poly(sebacic anhydride) sustained release preparations, biocompatibility, biodegradation, drug delivery materials

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