Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (22): 3603-3608.doi: 10.3969/j.issn.2095-4344.3175

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Development of high molecular polymer polyetherketoneketone and its prospects in medical applications

Wen Zhijing1, Gu Pengzhen1, He Xijing1, 2, Li Jialiang1, Wang Yibin1, Wang Yiqun1   

  1. 1Department of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China; 2Xi’an International Medical Center Hospital, Xi’an 710100, Shaanxi Province, China
  • Received:2020-06-18 Revised:2020-06-24 Accepted:2020-07-29 Online:2021-08-08 Published:2021-01-21
  • Contact: He Xijing, MD, PhD, Professor, Doctoral supervisor, Chief physician, Department of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China; Xi’an International Medical Center Hospital, Xi’an 710100, Shaanxi Province, China
  • About author:Wen Zhijing, Doctoral candidate, Department of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
  • Supported by:
    the World-Class Universities (Disciplines) and the Characteristic Development Guidance Funds for the Central Universities, No. PY3A023 (to HXJ)

Abstract: BACKGROUND: Polyetherketoneketone has excellent biocompatibility and is widely used in biomedical fields such as spine, joint and oral and maxillofacial surgery.
OBJECTIVE: To summarize the synthesis of polyetherketoneketone and its research progress in medical applications.
METHODS: PubMed, Web of Science and CNKI databases were searched for the articles concerning about the synthesis and development of polyetherketoneketone and their applications in the field of biomedicine with the search terms of “polyetherketoneketone, synthesis, scaffold material, implant, tissue engineering, biocompatibility” in English and Chinese, respectively. After initial screening of all articles according to inclusion and exclusion criteria, articles with higher relevance were included for review.
RESULTS AND CONCLUSION: In recent years, with the rise of the combination of medical and engineering, polyetherketoneketone and its composites have been gradually applied to the fields of orthopedics, oral and maxillofacial surgery. In orthopedics, polyetherketoneketone and its compounds modified with different physical and chemical properties can not only maintain the elastic modulus similar to human bones, increase the hardness, but also improve its biocompatibility, increase its antibacterial properties, and promote osseointegration. In oral and maxillofacial surgery, it can be used as a dental implant matrix, frame, and snap ring for removable partial dentures. Polyetherketoneketone can not only maintain good aesthetic advantages, but also has good fatigue resistance and retention, which is comparable to the oral cavity. The bonding system can ensure sufficient bonding ability, so polyetherketoneketone has great potential as a dental restoration material. In-depth research on the modification of polyetherketoneketone and its compound is still a hot topic. Through continuous improvement of the performance of the material, more in vivo and in vitro experiments have been carried out to confirm the superiority of polyetherketoneketone as an implant material for orthopedics and oral and maxillofacial surgery to make clinical transformation and it will have very good application prospects.

Key words: bone, material, polyetherketoneketone, implant, scaffold material, biocompatibility, tissue engineering, research progress, review

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