Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (22): 3584-3590.doi: 10.3969/j.issn.2095-4344.3120

Previous Articles     Next Articles

Application progress of conductive composite materials in the field of tissue engineering treatment of myocardial infarction

Lang Limin1, He Sheng2, Jiang Zengyu2, Hu Yiyi3, Zhang Zhixing1, Liang Minqian1   

  1. 1School of Medical Imaging, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China; 2Department of Imaging, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China; 3First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • Received:2020-05-07 Revised:2020-05-13 Accepted:2020-06-29 Online:2021-08-08 Published:2021-01-21
  • Contact: Jiang Zengyu, Chief physician, Professor, Master’s supervisor, Department of Imaging, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • About author:郎丽敏,女,1991年生,山西省吕梁市人,汉族,山西医科大学医学在读硕士,目前主攻心肌梗死的再生医学研究。
  • Supported by:
    the National Natural Science Foundation of China (Youth Program), No. 81900274 (to HS); the Key Research & Development Project in Shanxi Province, No. 201803D31106 (to JZY); the University Science and Technology Innovation Plan of Shanxi Education Department, No. 2019L0405 (to HS); the Applied Basic Research Project of Shanxi Province, No. 201801D221275 (to HS); Innovation Project of Graduate Education in Shanxi Province, No.2020SY250 (to LLM)

Abstract: BACKGROUND: In recent years, many new conductive materials have provided a new direction for translational medicine treatment of myocardial infarction.
OBJECTIVE: To classify and summarize conductive materials mentioned in the current literature, and review their research progress. 
METHODS: The key words were “biomaterial, nanomaterial, myocardial infarction, polypyrrole, polyaniline” in English and “biomaterials, myocardial infarction, heart tissue engineering” in Chinese. PubMed, Web of Science, Embase, CNKI, Wanfang, Vip and Chinese biomedical literature databases were retrieved for relevant literature published from 2015 to 2020. 
RESULTS AND CONCLUSION: Currently, in the field of myocardial infarction treatment, conductive biomaterials were divided into three categories: electroactive polymers (polypyrrole, polyaniline, polythiophene), carbon nanomaterials (grapheme and carbon nanotubes), and gold nanomaterials. These materials could be used in animal experiments to repair infarcted areas in the form of hydrogel or heart film patch. These materials, compared with traditional materials, had also shown better conductivity in vivo and in vitro experiments. The process of making materials, however, involved more multi-step synthesis reaction. Whether these materials could ensure low cytotoxicity and stability, there was no method or standard that could be accurately evaluated. At present, the conductive composites have only obtained promising effects in small animal myocardial infarction models. The safety and effectiveness of large animal models are still to be verified.

Key words: material, myocardial infarction, tissue engineering, biomaterials, electroactive polymers, nanomaterials, review

CLC Number: